Circular RNAs (circRNAs) have been implicated in cancer, but it is unknown how mutations in splicing factors may impact on circRNA biogenesis. Here, we used RNA-sequencing to investigate the effects of U2AF1 mutations on circRNA expression in K562 cells with a doxycycline-inducible U2AF1S34 ...
In this review, we found that tumour-derived extracellular circRNAs associated with drug resistance played a double-edge “pro- and anti-oncogenic” role in the advancement of cancer treatment through various mechanisms, such as acting as miRNA sponges, that circRNAs can function as microRNA (miRNA...
2,3]. With the introduction of RNA-sequencing (RNA-seq) technology and bioinformatics, thousands of circRNAs are shown to be abundant in eukaryotic cells [2,3,4,5]. Moreover, the simultaneous use of prediction tools
single-stranded, complete ring structure with no free 3′ or 5′ ends. CircRNAs are highly abundant and stable in the cytoplasm, as most of them are resistant to RNase. A variety of gene structures generate circRNAs mainly via a type of alternative RNA splicing called ‘back-splicing’ [1...
ciRS-7 circular RNA sponge for miR-7 HCC hepatocellular carcinoma CRC colorectal cancer PCR polymerase chain reaction qPCR quantitative PCR RT-PCR reverse transcription-PCR GC gastric cancer TNM tumor node metastases AML acute myloid leukemia CLL chronic lymphocytic leukemia CML chronic myeloid leukemia...
circRNA was successively detected in yeast and hepatitis delta virus (HDV), indicating that continuous loop structures of RNA might not be an accidental phenomenon.45,46However, the underlying mechanism of circRNA formation is still unclear. In 1987, circRNA was proposed to form by the ligation of...
Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as nonfunctional products of pre-mRNA mis-splicing. Currently, circRNAs have been proven to manipulate the functions of diverse molecules, including non-coding RNAs, mRNAs, DNAs and proteins, to regulate cell acti...
26 These results indicate that circ-Dnmt1 and circCDYL act as oncogenes by activating autophagy in BC. In one study of epithelial ovarian cancer (EOC), RNA sequencing analysis revealed that all circRNAs generated from the gene MUC16 were significantly elevated compared to normal ovarian tissue....
Article Open access 27 June 2022 A protein-encoding CCDC7 circular RNA inhibits the progression of prostate cancer by up-regulating FLRT3 Article Open access 16 January 2024 Circ_0001671 regulates prostate cancer progression through miR-27b-3p/BLM axis Article Open access 28 May 2024 Introduc...
Circular RNAs (circRNAs) are a newly discovered type of biological molecule that belongs to the noncoding RNA family. Abundant evidence has shown that circRNAs are involved in the progression of various cancers. However, the particular functions of circR