Over the past decade, circular RNA (circRNA) research has evolved into a bona fide research field shedding light on the functional consequence of this unique family of RNA molecules in cancer. Although the method of formation and the abundance of ci
Over the past decade, circular RNA (circRNA) research has evolved into a bona fide research field shedding light on the functional consequence of this unique family of RNA molecules in cancer. Although the methodof formation and the abundance of circRNAs can differ from their cognate linear mRNA...
Over the past decade, circular RNA (circRNA) research has evolved into a bona fide research field shedding light on the functional consequence of this unique family of RNA molecules in cancer. Although the method of formation and the abundance of ci
Circular RNA: The main regulator of energy metabolic reprogramming in cancer cellsTo acquire the necessary energy from a frequently energypoor microenvironment and use this energy to maintain viability and generate new biomass is a common feature of cancer cell metabolism. The alterations in cancer...
Circular RNAs in cancer: new insights into functions and implications in ovarian cancerCircular RNA, MicroRNA, Ovarian cancerCircular RNAs (circRNAs) are a class of long non-coding RNAs (lncRNAs) which have a circular and closed loop structure. They are ubiquitous, stable, conserved and diverse ...
CircMEMO1作为一个关键的表观遗传修饰因子,还可以调节肝癌细胞对索拉非尼治疗的敏感性。该研究成果发表在国际著名学术期刊Molecular Cancer(IF: 27.401)上。(芯片实验由康成生物丨数谱生物提供技术服务) 研究背景 肝细胞癌(hepatocelluar carcinoma,HCC)是最常见的恶性肿瘤之一,也是全球第三大癌症相关死亡原因。肝硬化...
CircRNA 是一种由共价闭合环化形成的新型内源性非编码 RNA,在肿瘤发生及发展中起着至关重要的作用 。很少有研究报道CircRNA在HCC与癌旁组织的发育异常结节(DN)中的表达情况。 研究思路 本文作者采用Arraystar Human CircRNA芯片及激光捕获显微切割(LCM)技术,分析了肝癌组织和癌旁DN组织中CircRNA的表达谱。然后,利用体...
Circular RNAs Cancer Functions Biomarker 1. Introduction Circular RNAs (circRNAs) were initially found in a plant-based virus in 1976 and described as “covalently closed circRNAs molecules”[1], [2]. However, circRNAs were originally considered to be the byproducts of aberrant RNA splicing and ...
In this issue of Cancer Cell , Teng etal. discover that small cell lung cancer and neuroendocrine prostate cancer highly express a circular RNA known as circRMST. They show that circRMST is necessary for these neuroendocrine cancers to promote their ASCL1-positive neuroendocrine phenotype through ...
The study’s aim was to explore a novel miRNA/mRNA network mediated by circNINL in cervical cancer (CC). Tumor tissue specimens and normal tissue spec