BEIJING, March 23 (Xinhua) -- Chinese researchers have built an open database on Circular RNAs, laying the groundwork for studies on the novel class of RNAs with important biological implications. RNA comes in many shapes and sizes. In recent years, Circular RNAs (circRNAs), a type of RNAs...
circVAR database: genome-wide archive of genetic variants for human circular RNAsBackground Circular RNAs (circRNAs) play important roles in regulating gene expression through binding miRNAs and RNA binding proteins. Genetic variation of circRNAs may affect complex traits/diseases by changing their ...
building a comprehensive circular RNA database become imperative. Several databases of the circRNA have been published, such as circBase, circRNABase and Circ2Trait14,15,16. The circBase merged and unified data sets of circRNAs from public references, with the evidence supporting their expression w...
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1B). The back-splicing is induced by base pairing of complementary sequences resided in the introns flanking circularizable exons, and these RNA pairs are usually derived from either non-repetitive complementary sequences or short interspersed nuclear elements, for instance, Alus and mammalian-wide...
circBase: a database for circular RNAs. Rna. 2014;20:1666–70. Article Google Scholar Lin Y, Pan X, Shen HB: lncLocator 2.0: a cell-line-specific subcellular localization predictor for long non-coding RNAs with interpretable deep learning. Bioinformatics 2021. Wang S, Wang Y, Wang S, ...
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Circular RNAs (circRNAs) have emerged as a prominent class of covalently closed single-stranded RNA molecules that exhibit tissue-specific expression and potential as biomarkers in extracellular vesicles (EVs) derived from liquid biopsies. Still, their c
(B) circE2F2 was predicted to have potential binding sites for HuR by CircInteractome database. (C) OC cell lysates were incubated with circE2F2 probe- or oligo probe-coated magnetic beads overnight. Total RNA was isolated for the measurement of HuR expression by Western blot. (D) OC ...
Unfortunately, circBase is currently static and it would be beneficial to the field if this database was regularly updated with new circRNA candidates as well as a continuous removal of false-positive circRNAs. Currently, circRNA cancer research is also hampered by most publically available RNA-...