Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-...
Circular RNAs are a large group of non-coding RNAs with a closed-loop structure. circRNAs play significant roles in many biological processes as miRNA sponges, regulators for gene transcription, combining with RNA-binding proteins and translation of protein. Nowadays, circRNAs have become a research...
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs
Circular RNAs are a large class of animal RNAs with regulatory potency Nature, 495 (7441) (2013), pp. 333-338, 10.1038/nature11928 View in ScopusGoogle Scholar Pamudurti et al., 2017 N.R. Pamudurti, et al. Translation of CircRNAs Mol. Cell, 66 (1) (2017), 10.1016/j.molcel.2017....
et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495, 333–338 (2013). This article identifies circRNAs as a large class of post-transcriptional regulators that compete with other RNAs for binding by miRNAs and RBPs. Article CAS PubMed Google Scholar ...
Circular RNAs (circRNAs) are a class of endogenously expressed regulatory RNAs with a single-stranded circular structure. They are generated by back splicing and their expression can be tightly regulated by RNA binding proteins. Cytoplasmic circRNAs can
Circular RNAs are a large class of animal RNAs with regulatory potency Nature, 495 (2013), pp. 333-338 CrossrefView in ScopusGoogle Scholar Memczak et al., 2015 S. Memczak, P. Papavasileiou, O. Peters, N. Rajewsky Identification and characterization of circular RNAs as a new class of...
2013年随着Circular RNAs are a large class of animal RNAs with regulatory potency这篇文章发布的。对于circRNA,成环的剪接位点不能直接mapping会基因组。因此,首先,通过mapping筛选出这些未比对的reads;然后取这些reads两头的20bp,重新mapping到基因组上;接着,利用开发的方法检测这些短序列是否是circRNA的短序列。
Circular RNAs are a large group of noncoding RNAs that are widely expressed in mammalian cells. Genome-wide analyses have revealed abundant and evolutionarily conserved circular RNAs across species, which suggest specific physiological roles of these species. Using a microarray approach, we detected inc...
et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495, 333–338 (2013). Together with Hansen et al. (2013), this paper invigorated the circular RNA (circRNA) research field by identifying functional circRNAs acting as microRNA sponges. Article CAS PubMed...