除了细胞因子直接参与NK细胞的分化和功能外,炎症性细胞因子(IL-12, IL-15 和 IL-18)还可以在缺乏抗原的情况下赋予小鼠和人类NK细胞记忆样特征,称为细胞因子诱导的记忆样(cytokine-induced memory-like,CIML)NK细胞,这种现象2009年被哈佛大学休斯医学研究所的Cooper等人发现。 关键表型特征 CIML NK细胞的关键特征包括...
Most typically, the CIML NK cells are derived from a mononuclear cell fraction of peripheral blood or cord blood. In further contemplated aspects, the CIML NK cells are expanded and induced in a contained and automated production environment that substantially reduces operational complexity and ...
Further, we highlight the pre-clinical rationale and ongoing therapeutic application of CIML NK cells for adoptive immunotherapy in patients with hematologic malignancies. 展开 关键词: natural killer cell, innate memory, immunotherapy, cytokine, cytokine receptor, IL-12, IL-15, IL-18, human ...
Most typically, the CIML NK cells are derived from a mononuclear cell fraction of peripheral blood or cord blood. In further contemplated aspects, the CIML NK cells are expanded and induced in a contained and automated production environment that substantially reduces operational complexity and ...
Most typically, the CIML NK cells are derived from a mononuclear cell fraction of peripheral blood or cord blood. In further contemplated aspects, the CIML NK cells are expanded and induced in a contained and automated production environment that substantially reduces operational complexity and ...