grid.7445.20000 0001 2113 8111Department of Brain Sciences, Charing Cross HospitalImperial College London W6 8RF London UKDiego N. Kaskihttps://ror.org/048b34d51grid.436283.80000 0004 0612 2631UCL Institute of NeurologyNational Hospital for Neurology Queen Square London UKToby J. Ellmers...
Chronic small vessel disease (SVD) has been shown to disrupt this network’s integrity and has been proposed as a predictor of poor outcome after stroke. We studied this hypothesis in patients with acute ischemic stroke of the striatocapsular region, an area of pronounced cortical and ...
et al. Global burden of small vessel disease-related brain changes on MRI predicts cognitive and functional decline. Stroke 51, 170–178 (2020). Article PubMed Google Scholar Chen, H. H. et al. The diagnostic accuracy of the Ascertain Dementia 8 questionnaire for detecting cognitive ...
Cerebral small vessel diseaseIn view of the high prevalence, cognitive abnormalities have a direct relevance in patients with chronic kidney disease. Characterized by cognitive slowing, attention deficits, disturbances in the planning, initiation and implementation of actions as well as language and...
Introduction Structural and functional impairments of cerebral small vessels (CSVs) result in white matter hypo-perfusion and ischemia that are major cause of Cerebral small vessel disease (CSVD) or white matter disease is a variety of abnormalities in brain microvasculature. Recently, chronic kidney ...
automatic reconstruction of the vasculature in a 2.25-mm optical section was performed with the Vesselucida 360 software (approximate coordinates interaural 7.2–4.0 mm). Tracing of the hippocampal region was based on corresponding images in a rat brain atlas [62]. A voxel scooping algorithm was ...
Thus, the allostatic load accumulated during early life phases can pervasively impact on animal’s biology, setting the stage for the emergence of phenotypes vulnerable to the onset of many and different pathologies during adult life, including cardiovascular disease, type 2 diabetes, emotional ...
M. et al. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Sci. Transl. Med. 10, eaam9507 (2018). Article PubMed Google Scholar Niu, J. et al. Aberrant oligodendroglial–vascular interactions disrupt the blood–brain barrier, ...
Chronic kidney disease, 24-h blood pressure and small vessel diseases are independently associated with cognitive impairment in lacunar infarct patients. Hypertens Res 2011; 34: 1276–1282. 10 Imai E, Horio M, Nitta K, Yamagata K, Iseki K, Tsuka- moto Y, Ito S, Makino H, Hishida A, ...
Arterial stiffness (AS) and chronic kidney disease (CKD) are common in the older population. AS results in increased pulsatile pressure, elevated pulse pressure (PP), and is linked to hypertension. PP is a surrogate for AS. The kidney has low vascular re