Methods based on chromosome conformation capture (3C) detect spatial proximity between genomic sequences in the context of cell nuclei and provide an invaluable a tool to investigate chromosome structure. 3C-based methods have revealed that chromosomes are folded in a complex hierarchy of structural ...
Micro Capture-C (MCC) is a chromatin conformation capture (3C) method for visualizing reproducible three-dimensional contacts of specified regions of the genome at base pair resolution. These methods are an established family of techniques that use proxi
Here we introduce a highly scalable, generally accessible, droplet-based single-cell Hi-C method, Droplet Hi-C, which combines an in situ chromosomal conformation capture (3C) assay with commercially available droplet microfluidics, to simultaneously capture the three-dimensional genome structure from ...
翻译 chromatin-conformation-capture 翻译 染色质构象捕获 以上结果来自机器翻译。 释义
The chromosome-conformation-capture (3C) technique applied to a specific genomic DNA region within budding yeast cells implied that yeast chromatin in a transcriptionally active domain did not form a compact 30-nm chromatin fiber but rather was extended with a loose arrangement of 10-nm fibers (...
Discover how Oxford Nanopore's end-to-end Pore-C chromatin conformation capture technique provides long-range contact information and characterisation of base modifications in the same dataset.
In non-plant species, the application of a 3C (chromatin conformation capture)-based method named Hi-C has greatly advanced our understanding of genome packing. In particular, Hi-C has revealed that TADs (topologically associating domains) are a predominant structural feature in most organisms [7...
From chromosome conformation capture (3C), chromosome conformation capture-on-chip (4C), chromosome conformation capture carbon copy (5C), to Hi-C, chromatin conformation capture techniques lack specificity to a specific protein [13,33,51,292,293]. To improve the specificity, Fullwood et al. [...
Abbreviations 3C: Chromatin conformation capture; 3D: Three-dimensional; APOLO: AUXIN- REGULATED PROMOTER LOOP; crwn1: crowded nuclei 1; FISH: Fluorescent in situ hybridization; FLC: FLOWERING LOCUS C; FT: FLOWERING LOCUS T; IHI: Interactive heterochromatic island; KEE: KNOT engaged elements; lnc...
Hi-C is an adaptation of the chromosome conformation capture (3C) methodology20 that identifies long-range chromosome interactions in an unbiased fashion without a priori target site selection. The frequency of long-range consensus interactions decays rapidly as linear distance along a chromosome ...