Using technologies based on chromosome conformation capture, such as Hi-C, we now have the possibility to study the three-dimensional organization of the genome at unprecedented resolution, shedding light onto a previously unexplored level of nuclear architecture. In plants, research in this field is...
2018年8月15日,Horticulture Research在线发表了中国农业科学院蔬菜花卉研究所王晓武老师与百迈客生物科技有限公司共同合作文章“Improved Brassica rapa reference genome by single-molecule sequencing and chromosome conformation capture technologies”。文章中利用～57xPacBio + ~456xBioNano + ~164xHi-C数据,更新了...
Recent multi-way chromosome conformation capture (3C) technologies, such as Pore-C, require development of methods for analysis of multi-way interactions. Hypergraphs are mathematically tractable objects that can be utilized to precisely represent and analyze multi-way interactions. Here we present the ...
Chromosome conformation capture (3C) technologies can be used to investigate 3D genomic structures. However, high background noise, high costs, and a lack of straightforward noise evaluation in current methods impede the advancement of 3D genomic research. Here we developed a simple digestion-ligation...
To obtain longer chromosome-level haplotypes, chromosome conformation capture technologies, such as Hi-C [13] have been used in haplotype-aware assemblies [14,15,16,17,18,19]. FALCON-Phase [14] uses the results of FALCON-Unzip [11] as input and phases haplotypes using Hi-C. The Hi-C ...
This detailed book collects methods based on the evolution of the chromosome conformation capture (3C) technique and other complementary approaches to dissect chromatin conformation with an emphasis on dissection of nuclear compartmentalization and visua
Recently, chromosome conformation capture (3C) based technologies, such as ... ZZ Zhang,G Li,KC Toh,... - Springer Berlin Heidelberg 被引量: 30发表: 2013年 Hi-C 2.0: An optimized Hi-C procedure for high-resolution genome-wide mapping of chromosome conformation Chromosome conformation capture...
Genome-wide chromatin conformation capture assays provide formidable insights into the spatial organization of genomes. However, due to the complexity of the data structure, their integration in multi-omics workflows remains challenging. We present data structures, computational methods and visualization tool...
Long-read DNA sequencing, optical mapping methods, and chromatin conformation capture techniques have been widely applied in whole-genome sequencing. These technologies are increasingly allowing chromosome-scale assemblies to be achieved [16]. At present, the nomenclature for newly assembled chromosomes is...
[1]. In recent years, rapid development of long-read sequencing technologies and high-throughput chromosome conformation capture (Hi-C) methods has facilitated the generation of plant genome assemblies at the chromosome level [1,2,3,4]. The high-quality reference genomes and relevant phylogenomic ...