For this high level of compaction, DNA is not packaged directly into the structure of chromatin. Rather, there are several hierarchies of organization. The initial packing is achieved by wrapping DNA around the nucleosome. This gives a packing ratio of 6. This packing is the same for both ...
Nature Chemical Biology5,462–464 (2009)Cite this article 3484Accesses 310Citations 4Altmetric Metrics ACorrigendumto this article was published on 01 September 2009 This article has beenupdated Abstract Loss-of-functionAspergillus nidulansCclA, a Bre2 ortholog involved in histone H3 lysine 4 methylat...
on certain “excesses” and keep fit (in both body and mind) to maintain a healthy aging process. Now, a team of fitness enthusiasts has revealed that long-term treatment with the diabetes drug metformin maintains an aging population of monkeys “in form,” including at the epigenetic level!
Genomic libraries of Planococcus lilacinus, a mealybug in which paternal chromosomes are facultatively heterochromatic and inactive in sons but not in daug... HS Mohan KNChandra - 《Molecular Biology Reports》 被引量: 0发表: 2005年 Chromatin and histones in mealy bug cell explants: activation and...
Intact nuclei were probed with DNAase-I-based probes and the resultant single strand pieces indicate that many or all of the nucleosomes exist in structures that cause every second nucleosome in a series to be resistant to attack. The effect is observed with chicken erythrocyte nuclei, rat liver...
9 proposed that compartmentalization of active and inactive chromatin, at the level of individual genes, underlies the formation of insulated chromatin domains. This model predicts that, when a developmentally regulated gene is active, its domain would merge with or have increased interactions with ...
BMC Biology volume 20, Article number: 274 (2022) Cite this article 5155 Accesses 15 Citations 10 Altmetric Metrics details Abstract Background Root development and function have central roles in plant adaptation to the environment. The modification of root traits has additionally been a major ...
1、Chapter 7,Chromosomes, chromatin, and the nucleosome,Molecular Biology of the Gene - James Watson et al.,Part I: Chemistry and Genetics Part II: Maintenance of the Genome Part III: Expression of the Genome Part IV: Regulation Part V: Methods,Ch 6: The structures of DNA and RNA Ch 7...
One of the major challenges in molecular biology is to characterize the mechanisms governing the regulation of transcription. Mechanisms of regulation can be broadly classified in three classes: (1) interaction of a control factor with DNA, (2) interaction of a control factor with the transcriptiona...
Recent studies have demonstrated that these inputs are much broader than had previously been known, encompassing metabolism from a wide variety of sources, including alcohol and microbiotal metabolism. These factors modify DNA and histones and exert specific effects on cell biology, systemic physiology...