2). In the interpretation of the equilibrium binding data it is, however, important to bear in mind that, under these conditions, the AChR is desensitized. The equilibrium binding results do not, therefore, provide information on theagonistbinding to the resting state of the AChR, and their ...
P. (1987) Cholinergic agonist and antagonist interactions on motor nerve endings of the rat-evidence for the involvement of presynaptic receptors in the regulation of acetylcholine release. Gen. Pharmac. 18, 75-81.Prado WA, Corrado AP (1987) Cholinergic agonist and antagonist interactions on motor...
Cholinergic agonist and antagonist drugs modulate the growth hormone response to growth hormone-releasing hormone in the rat: evidence for mediation by som... Recently, data have been presented showing that muscarinic cholinergic agonists or antagonists can modulate, in opposite ways, GH-releasing hormo...
The adrenocortical response to cholinergic agonist and antagonist agents were investigated in intact, hypophysectomized and medullectomized rats. The administration of peripherally active compound neostigmine, was found to cause a significant rise of corticosterone in the intact, and the hypoptiysecto...
Related to cholinergic agonist (2):Adrenergic agonist ag·o·nist (ăg′ə-nĭst) n. 1.PhysiologyA contracting muscle that is resisted or counteracted by another muscle, the antagonist. 2.A substance that can combine with a receptor on a cell to initiate signal transduction. ...
Acetylcholine regulates various cognitive functions through broad cholinergic innervation. However, specific cholinergic subpopulations, circuits and molecular mechanisms underlying recognition memory remain largely unknown. Here we show that Ngfr+ choli
Acetylcholine, carbachol and tetramethylammonium were used as agonists. The effects of the drugs on agonist-induced isometric contractions and depolarizations were studied. Logarithmic plots of (dose ratio–1) against antagonist concentration yielded regressions with slopes greater than unity when mono...
This study evaluated the effects of the cholinergic agonist pilocarpine and the cholinergic antagonist scopolamine on kindling rates and kindling-induced mossy fiber sprouting in adult rats. The results showed that pilocarpine accelerated kindling rates and enhanced kindling-induced mossy fiber sprouting in...
4) nicotinic acetylcholine receptor agonist 烟碱型乙酰胆碱受体激动剂 1. 3D-QSAR of nicotinic acetylcholine receptor agonists; 烟碱型乙酰胆碱受体激动剂的3D-QSAR研究5) cholinergic antagonists 胆碱能拮抗剂6) cholinergic antagonist 胆碱能阻断剂 1. The peripheral cholinergic antagonist,methylscopolamine(...
Neurite outgrowth was strongly inhibited by the muscarinic receptor agonist oxotremorine (5-100 microM) and weakly inhibited by nicotine (50 nM to 10 microM). The inhibitory effect of CCh was decreased by the muscarinic receptor antagonist atropine (10 microM), demonstrating that the effect of ...