Cholesterol-rich lipid rafts have been shown to play important roles in the life cycle of various non-enveloped and enveloped viruses. Deletion of cholesterol from lipid rafts could influence different steps of viral replication cycle including entry, infection, assembly and release. Caprine ...
Indeed, a critical role of cholesterol-rich microdomains (lipid rafts) has been described for the entry or release of RSV36,37, and it was recently found that cholesterol is required for RSV infectivity and stability38. Moreover, important advances have been made regarding the role of autophagy...
Cholesterol-enriched membrane microdomains, generally referred to as "lipid rafts", exist within the lipid bilayer of all mammalian cells and play an important role in signaling from the cell surface to various subcellular compartments. Lipid rafts have also been implicated in tumor growth and ...
Donati RJ, Rasenick MM (2005) Chronic antidepressant treatment prevents accumulation of Gsα in cholesterol-rich, plasma membrane domains (Lipid Rafts). Neuropsychopharm 30:1238–1245Donati RJ, Rasenick MM (2005) Chronic antidepressant treatment prevents accumulation of gsalpha in cholesterol-rich, ...
CHT association with cholesterol-rich rafts is critical for its function, and alterations in plasma membrane cholesterol could diminish cholinergic transmission by reducing choline availability for acetylcholine synthesis. 展开 关键词: cholesterol high-affinity choline uptake lipid rafts trafficking transport ...
Angiotensin II (Ang II) induces transactivation of the epidermal growth factor (EGF) receptor (EGF-R), which serves as a scaffold for various signaling molecules in vascular smooth muscle cells (VSMCs). Cholesterol and sphingomyelin-enriched lipid rafts are plasma membrane microdomains that concen...
JAM-A was not co-immunoprecipitated with the other TJ proteins indicating that it is resident within in a distinct population of rafts and therefore is likely not directly associated with the claudins/occludin present in the TJ complexes. Depletion of Caco-2 cell cholesterol with methyl-beta-...
Cholesterol-enriched membrane microdomains (lipid rafts) play a role in the uptake of many pathogens. Mycobacteria are one of the intracellular pathogens that utilize lipid rafts in order to invade both phagocytic and non-phagocytic cells. However, the mechanism of Mycobacterium tuberculosis uptake by...
For this purpose, model membranes mimicking the composition of lipid rafts and PC- or PE-Cho-rich domains were examined in the absence and presence of 2OHOA by synchrotron X-ray diffraction, atomic force microscopy (AFM) and microcalorimetry (DSC) techniques. Our results demonstrate that 2OHOA...
R. (2002) Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells. Cancer Res. 62, 2227-2231Zhuang L, Lin J, Lu ML, Solomon KR, Freeman MR: Cho- lesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells. Cancer Res...