However, the limited exchange between the central nervous system and peripheral circulation, due to the presence of the blood-brain barrier, necessitates cholesterol in the brain to be exclusively acquired from local de novo synthesis. This cholesterol is reutilized efficiently, rendering a much ...
First, an overview of the brain's unique shades of color: The brain appears white in some areas and gray in others due to the presence of myelinated axons in the white matter. Myelin is a fatty substance that wraps around the axons of neurons. This insulation—t...
In view of the very low rate of cholesterol synthesis in the brain of adult primates (2), it was suggested that this flux may be of importance for cholesterol homeostasis in the brain. It was also shown that the levels of 24S-hydroxycholesterol in the circulation are markedly age-dependent ...
Major advances in understanding cholesterol dynamics and the role that cholesterol plays in vascular disease have recently been made. The brain is an organ that is highly enriched in cholesterol, but progress toward understanding brain cholesterol dynamics has been relatively limited. This review examines...
a sterol, C27H46O, abundant in animal fats, brain and nerve tissue, meat, and eggs, that functions in the body as a membrane constituent and as a precursor of steroid hormones and bile acids: high blood levels are associated with arteriosclerosis and gallstones. ...
At the cellular level, peroxisomes are found in both neurons and glial cells including astrocytes, oligodendrocytes, and ependymal cells [3]. In neurons, peroxisomes are largely localized in the somata with a few in the proximal dendrites as well [4]. One of the main functions that brain ...
The meaning of CHOLESTEROL is a waxy, fat-like substance C27H46O that is found in the cells, tissues, and body fluids of humans and animals and that serves as a component of cell membranes and functions as a precursor of vitamin D and steroid hormones (s
the quantitative determination of cholesterol in brain lipid extracts using gas—liquid chromatographydoi:10.1016/S0021-9673(01)85859-3J.A. LowdenElsevier B.V.Journal of Chromatography ALowden, J. A.: The quantitative determination of cholesterol in brain lipid extracts using gas-liquid chromatography...
In the brain, cholesterol is synthesized in situ but cannot be degraded nor cross the blood–brain barrier. The major exportable form of brain...会议名称: 16th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy 会议时间: 2008/10/01 ...
On the contrary, cholesterol depletion using cholesterol oxidase, which catalyses cholesterol degradation to cholest-4-en-3-one, induced a significant enhancement of long-term potentiation10. At the system level, the concentration of cholesterol in the brain is high compared to other tissues11 and ...