However, the limited exchange between the central nervous system and peripheral circulation, due to the presence of the blood-brain barrier, necessitates cholesterol in the brain to be exclusively acquired from local de novo synthesis. This cholesterol is reutilized efficiently, rendering a much ...
Cholesterol transport in the brain refers to the process of moving cholesterol among nerve cells using HDL-like particles and specific lipoprotein receptors, facilitated by astrocyte-derived enzymes and proteins. AI generated definition based on: Neurochemistry International, 2023 ...
Protein Cell 2015, 6(4):254–264 DOI 10.1007/s13238-014-0131-3 Protein & Cell REVIEW Cholesterol metabolism and homeostasis in the brain Juan Zhang, Qiang Liu& Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and ...
The theory that heart disease is "caused by cholesterol" has gone through several stages, and most recently the use of the "statin" drugs has revived it in a radical way. One consistent theme for fifty years has been that people should eat more polyunsaturated fat and less saturated fat, t...
First, an overview of the brain's unique shades of color: The brain appears white in some areas and gray in others due to the presence of myelinated axons in the white matter. Myelin is a fatty substance that wraps around the axons of neurons. This insulation—th...
MW:386.66 EINECS: Mol File:92543-08-3.mol Use (Cholesterol-d6) Cholesterol is the principal sterol of the higher animals. Cholesterol was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Cholesterol is the main constituent of gallstones. Labelled...
cDNA cloning of cholesterol 24-hydroxylase, a mediator of choles- terol homeostasis in the brain. Proc Natl Acad Sci USA 96:7238 -7243.Lund EG, Guileyardo JM, Russell DW (1999) cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad ...
Under normal conditions, essentially all of the cholesterol in the brain is synthesized locally (31). The blood-brain barrier prevents any real contribution from plasma lipoproteins (Fig. 2). Thus, mechanisms that remove cholesterol from the brain are required for cholesterol homeostasis. Outside ...
If plaque or a blood clot block the coronary arteries that carry blood to the heart, heart attack (myocardial infarction) can occur. A stroke occurs if arteries carrying blood to the brain are blocked. In adults, a desirable LDL reading is less than 100 mg/dL.High-density lipoprotein (HDL...
Cholesterol in the human body Cholesterol is a biologically important compound in the human body. It is produced by the liver and used in the manufacture of vitamin D, adrenal gland hormones, and sex hormones. Large concentrations of cholesterol are found in the brain, spinal cord, and liver....