SIGNIFANCE: The cardiometabolic effects of cholesterol may have additional implications on cerebrovascular and brain health.NIH/NIGMS - P20 GM113125.This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional ...
Cholesterol (Chol) fortifies packing and reduces fluidity and permeability of the lipid bilayer in vesicles (liposomes)-mediated drug delivery. However, under the physiological environment, Chol is rapidly extracted from the lipid bilayer by biomembranes, which jeopardizes membrane stability and results ...
To investigate the correlation the correlation between residual cholesterol (RC) and increased carotid intima-media thickness(cIMT) in non-diabetic individ
On this basis, we have previously begun to explore means of restoring cholesterol bioavailability in the brain of R6/2 mice, an HD mouse line that exhibits early and rapid progression of behavioural, molecular, and electrophysiological abnormalities, starting at 6 weeks of age. In one study, cho...
In the adult brain, neurons require local cholesterol production, which is supplied by astrocytes through apoE-containing lipoproteins. In Huntington’s disease (HD), such cholesterol biosynthesis in the brain is severely reduced. Here we show that this defect, occurring in astrocytes, is detrimental...
cholesterol level, the amount of dietary cholesterol entering the bloodstream also has a direct impact on the level of low-density lipoproteins (LDLs), the “bad” cholesterol that directly contributes to plaque formation in the arterial wall. It has been estimated that a 90% reduction of ...
Hajnal JV, Bryant DJ, Kasuboski L, Pattany PM, De Coene B, Lewis PD et al (1992) Use of fluid attenuated inversion recovery (FLAIR) pulse sequences in MRI of the brain. J Comput Assist Tomo 16(6):841–844CrossRef Havel RJ (2000) Genetic underpinnings of LDL size and density: a...
A noncalcifying lesion that is isodense with brain, round with a smooth outline, and located in the superiolateral bony orbit is typically seen on CT (5). Postcontrast CT scans show no enhancement of cholesterol granulomas (6). On MRI, a cholesterol granuloma show bright signal intensity ...
International Journal of Nanomedicine 12 March 2010 Number of times this article has been viewed Objective: To evaluate the cytotoxicity of iron nanoparticles on cardiac cells and to determine whether they can modulate the biological activity of 7-ketocholesterol (7KC) involved in the development of...
Paul A. Tunick, Itzhak Kronzon Explore book CHOLESTEROL CRYSTAL EMBOLIZATION Cholesterol crystal embolization is a dramatic but uncommon syndrome. It is characterized by diffuse showering of the distal circulation with cholesterol crystals originating from arterial plaque, usually in the aorta (Fig. 47-...