Cholesterol turnover in myelin is very slow while turnover in neurons may be very rapid. (NIH 5R01 HL09610).doi:10.1096/fasebj.23.1_supplement.434.2John M. DietschyThe FASEB JournalDietschy, J. M. (2009). Mutations in NPC1 and cholesterol metabolism in the brain. FASEB J. 23....
This narrative review provides an overview of cholesterol metabolism in the brain along with several examples from the adult literature where pathologic alterations in cholesterol metabolism have been associated with inflammatory and ischemic brain injury. Using those data as a background, the review ...
The analysis of oxysterols is a valuable tool to noninvasively investigating the role of cholesterol metabolism in the pathogenesis of neurodegeneration.doi:10.1007/978-1-62703-598-9_9Luigi IulianoValerio LeoniHumana Press
Our results suggest that altered cholesterol metabolism in the brain has implications for synaptic plasticity as well as learning and memory.doi:10.1096/fasebj.20.4.A85Denise O'Donnell RamirezDepartment of Molecular GeneticsUniversity of Texas Southwestern Medical Center5323 Harry Hines Blvd.DallasTX75390...
The accumulation and aggregation of the amyloid-β peptide (Aβ) in the brain are important contributing factors to Alzheimer's disease (AD). Consequently, blocking the generation of Aβ is a potentially important treatment strategy. Recent work on the metabolism of Aβ has identified several ...
cholesterol metabolism in the brain are linked to neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and other atypical cognitive deficits that arise at old age. However, the specific role of cholesterol metabolism disorder in ...
Turley Cholesterol metabolism in the brain Curr. Opin. Lipidol., 12 (2001), pp. 105-112 View in ScopusGoogle Scholar [153] L. Iuliano, et al. Cholesterol metabolites exported from human brain Steroids, 99 (2015), pp. 189-193 View PDFView articleView in ScopusGoogle Scholar [154] J.J...
Despite the important roles of YTHDF2 in brain development and function, it is unknown whether this reader is presented in GBM and affects GBM propagation. Dysregulated cholesterol metabolism by cancer epigenetic regulators is another hallmark of GBM12. Cholesterol metabolism is under the ...
5.inflammatory histiocytosis associated with disturbance of cholesterol metabolism; occurs chiefly in young children and is characterized by cystic defects of the skull and diabetes insipidus.通常发生在年轻人身上的一种胆固醇代谢病症。 6.Brain β-amyloid Peptide and Cholesterol Metabolism in Rat;胆固醇代谢...
Wilson disease (WD) is an autosomal recessive inherited disorder of copper (Cu) metabolism, resulting in pathological accumulation of Cu in many organs and tissues, predominantly in the liver and brain. There clearly is a close and complex relationship between Cu and the cholesterol’s metabolic ...