Cholesterol function in plasma membranes from ectotherms: membrane-specific roles in adaptation to temperature. American Zoologist. v. 38, p. 291-304, 1998.Crockett EL. Cholesterol function in plasma membranes from ectotherms: membrane-specific roles in adaptation to temperature. Amer Zool 1998; 38:...
Cholesterol: Absorption, Function and Metabolism V. Vučić, Z. Cvetković, in Encyclopedia of Food and Health, 2016 Introduction Cholesterol plays an essential role in maintaining membrane integrity and proper fluidity. It is an abundant component of the plasma membranes of eukaryotic cells, whic...
Cells tightly control the ratio of cholesterol and phospholipids in membranes to best suit their biological functions. Within the plasma membrane, cholesterol segregated with sphingolipids and selective proteins form distinct lipid raft complexes that act as ordered platforms for communicating signals into ...
The composition of the plasma membrane of malignant cells is thought to influence the cellular uptake of cisplatin and to take part in developing resistance to this widespread anti-cancer drug. In this work we study the permeation of cisplatin through the model membranes of normal and cancer cells...
Cholesterol is a primary component of the mammalian cell plasma membrane. Although its function is unknown, it may be of major importance in maintaining membrane fluidity and rigidity 1 . In artificial membrane systems, the addition of cholesterol results in a condensing effect—thickening the bilayer...
Adequate cholesterol depletion and insertion into the membrane was monitored in intact cells and plasma membrane fractions by filipin fluorescence staining (Supplementary Figs 6 and 7) and targeted lipidomic analysis (Supplementary Fig. 1). Interestingly, addition of cholesterol significantly decreases [3H...
Cell-free transfer of sterols from dictyosome-like structures to plasma membrane vesicles of guinea pig testes The results from the cell-free analysis suggest a possible functional role of the DLS in sterol biogenesis and transfer to the plasma membrane during ... L Waits,S Dunkle,FE Wilkinson...
In this structural role, cholesterol reduces the permeability of the plasma membrane to neutral solutes, protons, and sodium ions. 体内研究:Cholesterol is recycled. The liver excretes it in a non-esterified form (via bile) into the digestive tract. Typically about 50% of the excreted ...
Therefore, graphene needs to be close to cell or tissue surfaces8 in order to maximize its utility in bioapplications. This then raises a fundamental question: how graphene affects the plasma membrane and related cellular functions. Prior studies have documented that graphene flakes (GFs) are ...
Transduction of Hedgehog signals across the plasma membrane is facilitated by the class F G-protein-coupled-receptor (GPCR) Smoothened (SMO). Recent studies suggest that SMO is modulated via interactions of its transmembrane (TM) domain with cholesterol. We apply molecular dynamics simulations of SMO...