Infusion of T cells engineered to express chimeric antigen receptors (CARs) that target B cells has proven to be a successful treatment for B cell malignancies. This success inspired the development of CAR T cells to selectively deplete or modulate
T cellsChimeric antigen receptor (CAR) T-cell therapy is a revolutionary approach in the treatment of lymphoma. This review article provides an overview of the four FDA-approved CAR T-cell products for aggressive B-cell lymphoma, including diffuse large B-cell lymphoma and m...
Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have demonstrated significant success in certain hematologic malignancies, although they still face certain limitations, including high costs and toxic effects. Natural kil...
Chimeric antigen receptor (CAR) T cell therapy involves the genetic modification of T cells to recognize and bind to specific cancer cell surface antigens, thereby enabling them to effectively target and eliminate cancer cells [1]. Since the approval of the first CAR-T cell product targeting the...
Chimeric antigen receptor (CAR) T cell is a novel approach, which utilizes anti-tumor immunity for cancer treatment. As compared to the traditional cell-me
Europa AzucenaGonzález-NavarroMartaEspañolNataliaEgriMariaCastellàHugoCalderónCarolinaEspañaCarlaGuijarroLibertadHerediaMarionaPascalManelJuan Otero, inInternational Review of Cell and Molecular Biology, 2022 Abstract Chimeric antigen receptor(CAR) is probably one of the most successful proposals for cancer...
Significantly, anti-CD19chimeric antigen receptorT cells (CAR-T cells) have shown remarkable efficacy in treating lymphoma that is resistant to chemotherapy. These CAR-T cells have the ability to induce long-lasting full remissions, surpassing a duration of 2years, in certain patients diagnosed wit...
Chimeric antigen receptor(CAR) is a synthesized transmembrane protein,which redirects the modified cells through specific or associated antigen on tumor cells.CAR-modified T/NK cells,especially CAR-T cells,are a new tool of rapidly developing of adoptive immunotherapy of tumor in recent years,they ...
One attractive strategy is to use T cells that have undergone genetic modification to express a chimeric antigen receptor capable of interacting with tumor antigens. In this article, we will review chimeric antigen receptor T-cell therapy, their advantages, drawbacks, challenges facing their use and...
Chimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment that has recently been undergoing rapid development. However, there are still some major challenges, including precise tumor targeting to avoid off-target or “on-target/off-tumor” toxicity, adequate T cell infiltration...