Chimeric antigen receptor (CAR) T-cell therapy involves effectively re-engineering a patient's T cells to combat cancer cells.The administration of CAR T-cell therapy may result in some side effects.Such side effects are Cytokine Release Syndrome and Immune effector cell-associated neurotoxicity ...
Antigen receptor structure and signaling FangHan, ...ZhiweiHuang, inAdvances in Immunology, 2023 4.6.4Chimeric antigen receptor (CAR) T and hematological malignancies Autologous CAR-T cell immunotherapy is highly regarded for its demonstrated remarkable therapeutic effects in the treatment of various ...
Chimeric antigen receptors (CARs): structure and function A CAR is a functional hybrid antigen receptor usually combining variable regions of an antibody with the constant region of a T cell receptor (TCR), grafting an immune cell with the specificity for TAA expressed on tumor cells [26]. A ...
Engineered T cells that express chimeric antigen receptors (CARs) have transformed the treatment of haematological cancers. CARs combine the tumour-antigen-binding function of antibodies with the signalling functions of the T cell receptor (TCR) ζ chain
19is derived from a murine monoclonal antibody11. One way to potentially reduce immunogenicity of CAR binding domains is to use human instead of murine sequences23,24. Another potential way to decrease immunogenicity of CARs is to simplify the structure of the CAR’s antigen-binding domain by ...
Human T cells modified with this synthetic receptor can specifically redirect tumor antigens and undertake the striking efficacy for many human malignancies [26–28]. Like that of the conventional T cell, the structure of CAR-modified T cell contains three moieties, i.e., an extracellular domain...
Enhancing the safety of CAR-NK cell-based therapy may involve modifying the CAR structure by incorporating suicide genes [154]. Developing bispecific CAR molecules to better target tumor-specific antigens is another crucial approach. CAR-NK cells exhibit the unique ability to target tumors in both...
摘要: The Chimeric Antigen Receptor (CAR) consists of an antibody-derived targeting domain fused with T-cell signaling domains that, when expressed by a T-cell, endows the T-cell with antigen specificity...关键词:Chimeric antigen receptor T-cell Retrovirus Lentivirus Transduction Transfection RNA ...
CAR-T cells against the carbohydrate portion of Lewis (Ley) have a fully-humanized structure to help in decreasing the immunogenic-related side effects. Bone marrow biopsies from 48 patients were tested for Lewis antigen expression it revealed that about 52% of those samples are indeed positive ...
The structure of the CAR was F0-F1-L1-Z-L2-F2-H-TM-C-CD3ζ, and the amino acid sequence was shown in SEQ ID NO.8. The above various coding sequences were assembled and amplified in vitro using nested-PCR to construct a chimeric antigen receptor coding sequence including a specifically...