As used herein, unless otherwise specified, each of the following terms should have the meaning given below. Other definitions are set forth throughout the application. Term “about” refers to one or more particular values within a range of acceptable tolerances as determined by one of ordinary...
Tumors with intratumor heterogeneity do not display antigens uniformly, meaning that a tumor may contain both antigen positive and antigen negative cells. We used 1:1 mixture of EGFRvIII-positive and -negative GL261 cells to mimic the intratumor antigenic heterogeneity and cocultured them with 806-...
resulting in a loss of TCR function. These modified T cells became anergic, meaning they were unable to respond to TCR-specific stimulation, and importantly, showed no imbalance in T cell subsets [49]. TCR-negative T cells have since been...
Meaning The results of this nonrandomized clinical trial indicate that CART is capable of anticancer activity in heavily pretreated mCRC by targeting a solid cancer antigen. Abstract Importance Chimeric antigen receptor (CAR) T-cell therapy (CART) has transformed the treatment landscape of hematologic...
The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a trans
Chimeric antigen receptor (CAR) T-cell immunotherapies targeting CD19 can achieve impressive clinical remission rates in the treatment of B-cell non-Hodgkin lymphoma and B-cell acute lymphoblastic leukemia. However, relapse after CD19-CAR T treatment remains a major issue, with CD19 antigen-negativ...
Multiplex targeted chimeric antigen receptor CAR-T cell therapy(Cellevolve) 靶点- 作用机制 免疫细胞毒性 [+1] 在研机构 Cellevolve Bio, Inc.初创企业 原研机构 Cellevolve Bio, Inc.初创企业 在研适应症 中枢神经系统肿瘤 非在研适应症- 最高研发阶段临床1期 首次获批国家/地区- 首次获批日期- 1 项与...
The in vivo fluorescence of MAT protein–XFP tags (XFP meaning any of the different fluorescent protein tags) during the predatory life cycle was examined. Approximately synchronous predation of E. coli S17-1 PZMR100 by B. bacteriovorus strains was prepared by combining a 10-times-concentrated ...
However, his pretreatment thrombocyte count was 79 Â 10e9 lÀ1 (scored as grade 2) meaning that the actual decrease after treatment was moderate. At baseline, 5 out of 18 patients (28%) had lower than normal thrombocyte counts (this is common in cancer patients). Four out of ...
1. A method of treating cancer, comprising: administering to a subject in need thereof a cell, wherein the cell comprises a) a chimeric antigen receptor (CAR), wherein the CAR comprises an antigen-binding domain specific for Glypican-3 (GPC3), and b) an armoring molecule, wherein the an...