Wachowius, FalkRes. Group Nucleic Acid Chem., MPI Biophys. Chem., D‐37077 Goettingen, GermanyWILEY‐VCH VerlagCheminformHöbartner C, Wachowius F (2010) Chemical synthesis of modified RNA. In: Mayer G (ed) The chemical biology of nucleic acids, vol 1. Wiley, Chichester, UK, pp 1–...
Synthesis of modified nucleotides and then incorporation into an RNA chain have facilitated our understanding of the functron and mode of action of specific nucleotides within the ribonucleic acid. Recent developments in the chemical and enzymatic synthesis of RNAs (1 –3 ) have allowed the introduct...
atoms, have remained largely unexplored for biomolecular applications. Here, the authors use an azo-ene-yne coarctate reaction to synthesize isoindazole-basedN-heterocycles and explore their applications in the synthesis of unnatural amino acids and drug conjugates, and late-stage peptide ...
The RNA fragment synthesis of (I)-(III), using ′perfectly′ protected monomer units such as (IVa)-(IVd), and the synthesis of ribo-oligonucleotides (V), by the solid-phase method, are described.doi:10.1002/chin.198638313T. HATAM. SEKINE...
Summary. Several oligoribonucleotide fragments which are related to the C4N hypothesis, were synthesized by both the liquid and solid phase methods via the phosphotriester approach, in which the combination of the 2-Thp group with the 5-DMTr group was used for chain elongation.doi:10.1080/...
atoms, have remained largely unexplored for biomolecular applications. Here, the authors use an azo-ene-yne coarctate reaction to synthesize isoindazole-basedN-heterocycles and explore their applications in the synthesis of unnatural amino acids and drug conjugates, and late-stage peptide ...
Rao, M.V. and Macfarlane, K., Improvements to the chemical synthesis of biologically active RNA using 2'-O-Fpmp chemistry. Nucleosides Nucleotides, 14 (1995) 911 913.Rao, M.V., Macfarlane, K., 1995. Improvements to the chem- ical synthesis of biologically active RNA using 2%-O-Fpmp...
For example, Ψ improves base-stacking interactions, as well as provides an additional hydrogen-bond donor, which can stabilize local RNA structure comparatively better than uridine at the same position [18], [19]. The accumulation of modified nucleotides in functionally important regions of the ...
chemical synthesisis possible for sequences up to 100amino acids. The N-terminus of the peptide should be acetylated to eliminate the unnatural positive charge of the protonated amino group. In contrast, the C-terminal end should not be modified because of the C-terminal nature of mGluR C-...
RNA synthesis information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook.