Synthesis & Applications of Dna & RnaOhtsuka, E. and Iwai, S. 1987. Chemical synthesis of RNA. In Synthesis and Applications of DNA and RNA (S.A. Narang, ed.) pp. 115-136. Aca- demic Press, San Diego.Ohtsuka et al., " Chemical Synthesis of RNA, " Synthesis and Application of DNA and RNA, 1987, pp. 115-132.Ohtsuka et al., Chem...
The RNA fragment synthesis of (I)-(III), using ′perfectly′ protected monomer units such as (IVa)-(IVd), and the synthesis of ribo-oligonucleotides (V), by the solid-phase method, are described.doi:10.1002/chin.198638313T. HATAM. SEKINE...
Summary. Several oligoribonucleotide fragments which are related to the C4N hypothesis, were synthesized by both the liquid and solid phase methods via the phosphotriester approach, in which the combination of the 2-Thp group with the 5-DMTr group was used for chain elongation.doi:10.1080/...
Rao, M.V. and Macfarlane, K., Improvements to the chemical synthesis of biologically active RNA using 2'-O-Fpmp chemistry. Nucleosides Nucleotides, 14 (1995) 911 913.Rao, M.V., Macfarlane, K., 1995. Improvements to the chem- ical synthesis of biologically active RNA using 2%-O-Fpmp...
The solid-phase synthesis of RNA sequences is also reviewed with a particular emphasis on the selection of 2′-hydroxyl protecting groups for ribonucleosides and their phosphoramidite derivatives to underscore this critical issue in the synthesis of RNA sequences. The in situ synthesis of DNA ...
Chemical synthesis occurs when two or more molecules are combined to form a product molecule that possesses specific properties.
Three-dimensional (3D) structures dictate the functions of RNA molecules in a wide variety of biological processes. However, direct determination of RNA 3D structures in vivo is difficult due to their large sizes, conformational heterogeneity, and dynami
C−H bond functionalization is widely used in chemical synthesis but achieving regio- and stereoselectivity is still challenging. Here, the authors report the mechanism of three Fe(II)/α-ketoglutarate-dependent dioxygenases in bicyclomycin synthesis, which depicts the natural strategy to sequentially...
研究成果发表于Nature、Chemical Reviews、Nature Metabolism、Advanced Science、Nature Synthesis、Nature Communications、Angew. Chem. Int. Ed.等国际知名学术期刊,共计发表SCI论文40余篇,申请专利68余项,授权15项。先后入选各级高层次人才项目,获...
研究成果发表于Nature、Chemical Reviews、Nature Metabolism、Advanced Science、Nature Synthesis、Nature Communications、Angew. Chem. Int. Ed.等国际知名学术期刊,共计发表SCI论文40余篇,申请专利68余项,授权15项。先后入选各级高层次人才项目,...