doi:10.1038/s41392-024-02089-4Kai Huanghttps://ror.org/056ef9489grid.452402.50000 0004 1808 3430Department of Medical OncologyQilu Hospital of Shandong University Jinan Shandong ChinaNature Publishing Group UKSignal Transduction and Targeted Therapy...
chemical inducers of proximity(化学亲和诱导剂) protein–protein interactions(蛋白质-蛋白质相互作用) proteolysis-targeting chimeras(蛋白降解靶向嵌合体) 研究背景 小分子诱导的蛋白质-蛋白质相互作用调节剂在生物医药领域具有重要意义,虽然挑战重重,但提供了广泛的治疗机会。 尽管抑制蛋白质-蛋白质相互作用已成为药物...
Chemical inducers of proximity employ a small molecule that can recruit protein pairs to the same position of a biological system. These proteins bind to different portions of the same small molecule. For example, FKBP (FK506-rapamycin binding protein) and FRB (FKBP-rapamycin binding domain of ...
DNA-encoded libraries are a powerful tool to identify novel chemical inducers of proximity such as targeted protein degraders, even without a known binder for the target protein. journal article LitStream Collection A new class of macrocyclic peptides ...
DNA-encoded libraries are a powerful tool to identify novel chemical inducers of proximity such as targeted protein degraders, even without a known binder for the target protein. Andrea Testa News & Views02 Nov 2023Nature Chemical Biology
R. Chemically induced proximity in biology and medicine. Science 359, eaao5902 (2018). This Review discusses the breadth of biological systems that have been studied with molecular glues known as chemical inducers of proximity (CIPs), primarily focusing on cases involving protein engineering. ...
(Fig.1e). Smaller, lower-density chromatin structures exhibiting fibrous morphology could also be observed. Adriamycin also induced larger, high-density structures located in close proximity to the nuclear lamina where the heterochromatin is associated (Fig.1f). Those results suggest that the dense ...
These are proximity-based assays that have successfully been used to study the activity of a wide range of targets [58–61]. The technology requires two bead types, termed donor beads and acceptor beads with the former containing the photosensitizer phthalocyanine, which converts ambient oxygen to...
MODIFIABLE CHEMICAL INDUCERS OF PROXIMITY AND METHODS OF USING THE SAMEMethods of reversibly inducing proximity of first and second target molecules in a sample are provided. Aspects of the methods include contacting the sample with a modifiable chemical inducer of proximity (MCIP) that reversibly ...
Alkenyl Substituted Cycloaliphatic Compounds as Chemical Inducers of ProximityMethods of inducing proximity of chimeric molecules in a cell are provided. Aspects of the methods include contacting a cell with an amount of alkenyl substituted cycloaliphatic (ASC) inducer compound, e.g., abscisic acid, ...