doi:10.1038/s41392-024-02089-4Kai Huanghttps://ror.org/056ef9489grid.452402.50000 0004 1808 3430Department of Medical OncologyQilu Hospital of Shandong University Jinan Shandong ChinaNature Publishing Group UKSignal Transduction and Targeted Therapy...
DNA-encoded libraries are a powerful tool to identify novel chemical inducers of proximity such as targeted protein degraders, even without a known binder for the target protein. Andrea Testa News & Views02 Nov 2023Nature Chemical Biology
Methods of inducing proximity of chimeric molecules in a cell are provided. Aspects of the methods include contacting a cell with an amount of alkenyl substituted cycloaliphatic (ASC) inducer compound, e.g., abscisic acid, effective to induce proximity of first and second chimeric molecules. Also...
MODIFIABLE CHEMICAL INDUCERS OF PROXIMITY AND METHODS OF USING THE SAMEMethods of reversibly inducing proximity of first and second target molecules in a sample are provided. Aspects of the methods include contacting the sample with a modifiable chemical inducer of proximity (MCIP) that reversibly ...
Methods of inducing proximity of chimeric molecules in a cell are provided. Aspects of the methods include contacting a cell with an amount of alkenyl substituted cycloaliphatic (ASC) inducer compound, e.g., abscisic acid, effective to induce proximity of first and second chimeric molecules. Also...