[3]Acetylcholine inhibits long-term hypoxia-induced apoptosis by suppressing the oxidative stress-mediated MAPKs activation as well as regulation of Bcl-2,c-IAPs,and caspase-3 in mouse embryonic stem cells[J].Min Hee Kim,Mi Ok Kim,Jung Sun Heo,Jin Sang Kim,Ho Jae Han.Apoptosis.2008(2) [...
Choline acetyltransferase (ChAT) as a rate-limiting enzyme in the biosynthetic pathway of acetylcholine is thought to be present in all cholinergic neurons. However, its immunoreactivity has not been successfull...
Constitutive expression of mRNA for the same choline acetyltransferase as that in the nervous system , an acetylcholine-synthesizing enzyme, in human leukemic T-cell lines. Neurosci Lett. 1999;259:71-74. [DOI] 2. Sailer M, Oppitz M, Drews U. Induction of cellular contractions in the ...
It catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA). CHAT is known to be present exclusively in the cytoplasm of cholinergic neurons and anti-...
室管膜下区(subventricularzone,SVZ)有表达胆碱乙酰基转移酶 (Cholineacetyl-transferase,ChAT)的神经元(ChAT + 神经元),其在生理及病理情 况下均可调控乙酰胆碱(acetylcholine,ACh)的分泌,从而促进神经发生。研究表 明,α7烟碱型乙酰胆碱受体(α7nicotinicacetylcholinereceptor,α7nAChR)在脑 梗死后有神经保护作用,...
CHAT (choline acetyltransferase) belongs to the carnitine/choline acetyltransferase family. It catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA). CHAT...
In Alzheimer's disease, the loss of basal forebrain cholinergic neurons results in a reduction of acetylcholine and its synthesizing enzyme, choline acetyltransferase ( ChAT ) (Nagei et al., 1983). The loss of cholinergic neurons in the basal forebrain is thought to play a role in the memory...
The best-characterized component of elapid venom is the alpha-neurotoxins, such as alpha-bungarotoxin and alpha-cobratoxin, which competitively antagonize nicotinic acetylcholine receptors resulting in paralysis and respiratory failure. Cardiotoxins are also present and can cause cardiac dysfunction and ...
M. A Distinct Functional Site in Ω-Neurotoxins: Novel Antagonists of Nicotinic Acetylcholine Receptors from Snake Venom. ACS Chem Biol. 10, 2805–2815 (2015). 31. Rajagopalan, N., Pung, Y. F., Zhu, Y. Z., Wong, P. T., Kumar, P. P. & Kini, R. M. Beta-cardiotoxin: a new ...
et al. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha- bungarotoxin and a mimotope peptide. Neuron 32, 265–275 (2001). 66. Girish, V. M. et al. Identification and structural characterization of a new three-finger toxin hemacha...