We have previously shown that muscarinic acetylcholine receptors (mAchRs) play an important role in the regulation of hepatic fibrosis and that the receptor agonists and antagonists affect hepatocyte proliferation. However, little is known about the impact of the different mAchR subtypes and associated ...
One of the ways that nicotine and cigarette smoke promote the growth of lung cancers is by promoting the production of ACh, which binds to its cognate receptor (on lung cancer cells) in an autocrine manner and induces the proliferation of lung cancer cells. The objective of the present study...
et al. The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice. J. Clin. Invest. 120, 2184–2193 (2010). Article CAS PubMed Central PubMed Google Scholar Kong, K. C. et al. M3-muscarinic receptor promotes insulin release via receptor ...
acute –cellular response417 –coronary syndrome440,459 –myocardial infarction458 –vascular response417 (ADAM)10390 addressin415 adenocarcinoma306 adenomatous polyposis coli(APC) 72,107 adenosine diphosphate(ADP) 440,444,446,451,452,459 –receptor460 adenovirus365 –receptor364 adherens junction23,24,...
Over the past 40 years, the muscarinic acetylcholine receptor family, particularly the M1-receptor and M4-receptor subtypes, have emerged as validated targets for the symptomatic treatment of neurological diseases such as schizophrenia and Alzheimer disease. However, despite considerable effort and investme...
nicotinic and muscarinic.They are named for chemicals that can selectively activate each type of receptor without activating the other:muscarine is a compound found in the mushroom Amanita muscaria(毒蝇鹅膏菌,拉丁学名:[Amanita miscaria (L.: Fr.) Pers. ex Hook.毒蝇伞],又称哈蟆菌、捕蝇菌、...
To determine which subtypes of ACh receptors and signaling pathway were involved, we examined the effect of receptor antagon- ists and inhibitors for selective pathway. Atropine (0.5 M), a muscarinic ACh receptor antagonist, blocked the ACh response, while D-tubocurarine (250 M), a nicotinic ...
Several therapeutic drugs act by modifying cholinergic transmission. Muscarinic acetylcholine receptor antagonists, such as trihexyphenidyl and benztropine, are used to treat Parkinson's disease and other movement disorders. Acetylcholinesterase inhibitors, which block the breakdown of acetylcholine and thereby ...
of activated beige adipocytes, we found that expression of the cholinergic receptor nicotinic alpha 2 subunit () was induced in subcutaneous fat during the activation of these cells and that acetylcholine-producing immune cells within this tissue regulated this signaling pathway via paracrine mechanisms....
Emerging approaches for treatment of schizophrenia: modulation of cholinergic signaling. Discov. Med. 14, 413–420 (2012). 27. Jones, C. K., Byun, N. & Bubser, M. Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia. ...