structure-activity relationship (SAR)Several series of 伪,伪-disubstituted polycyclic compounds were found to enhance the stimulus-induced release of neurotransmitters, especially acetylcholine, in brain slices. This work resulted in the identification of linopirdine [3,3-bis (4-pyridinylmethyl)-1, 3...
In the work recorded here, a series of trimethoxybenzoic acid esters are compared to determine the structure/activity relationship.doi:10.1038/204485b0BHATNAGAR, S. PLAM, AMCCOLL, J. DSpringer NatureNatureBhatnagnar, S.P. , Lam, A. & Mccoll, J.D. ( 1964 ). Inhibition of synthesis of...
The neuroanatomical locus by which mAChRs, and M4AChRs in particular, exert influence upon dopaminergic activity is not fully elucidated, but accumulating evidence suggests a strong relationship with dopamine D1 receptor function (Ince et al, 1997; Zhang et al, 2002). Specifically, M4 receptor ...
(1967). Relationship between acetylcholine and cholinesterase activity in the brain following an organophosphorus cholin- esterase inhibitor. Biochem. Pharmac., 16, 404-406.B. Holmstedt, M. Hlrkonen, G. Lundgren and A. Sundwall, Relationship between acetylcholine and cholinesterase activity in the ...
关键词: Erythrocytes Humans Thyroid Hormones Thyronines Diiodothyronines Triiodothyronine Triiodothyronine, Reverse Thyroxine Acetylcholinesterase Structure-Activity Relationship DOI: 10.1507/endocrj1954.32.753 年份: 1985 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 Semantic Scholar 万方医学 dx.doi...
Tonder et al., “Improving the Nicotinic Pharmacophore with a Series of (Isoxazole)methylene-1-azacyclic Compounds: Synthesis, Structure-Activity Relationship, and Molecular Modeling”, Journal of Medicinal Chemistry, vol. 42, No. 24 (1999), pp. 4970-4980. Udding et al., “Copper-Catalysed...
Over the past decade, studies of the atomic structure and the structural mechanism of nicotinic acetylcholine receptor (AChR) gating have reached an advanced stage. AChRs are members and prototypes of the superfamily of Cys-loop pentameric ligand-gated ion channels. AChRs are expressed by neurons ...
This review aims to give an overview of the knowledge we have today on the molecular pharmacology of conotoxins specifically interacting with nAChRs along with the structure–function relationship data. 展开 关键词: nicotinic acetylcholine receptor cone snail toxins α-conotoxins mode of action working...
The structure of migrastatin was determined to be a 14- membered ring macrolide containing a glutarimide, and that work was followed by total synthesis [3ϳ5]. Studies on the structure-activity relationship for cell migration led to the potent derivative, the migrastatin core which consists of ...
The cholinergic system is essential for memory. While degradation of cholinergic pathways characterizes memory-related disorders such as Alzheimer’s disease, the neurophysiological mechanisms linking the cholinergic system to human memory remain unknown