Some aspects of the disclosure relate to methods of characterizing the pre-infusion tumor microenvironment and determining an effective dose of a T cell immunotherapy.JOHN M. ROSSIADRIAN BOT
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A favorable regenerative microenvironment is essential for peripheral nerve regeneration. Neural tissue-specific extracellular matrix (ECM) is a natural material that helps direct cell behavior and promote axon regeneration. Both bone marrow-derived mese
The “seed and soil” hypothesis has been instrumental to our understanding of tumor metastasis and also provides an explanation for organotropism in metastasis: pro-metastatic tumor cells (the “seed”) colonize in specific organ sites (the “soil”) where the microenvironment is favorable for ...
Several types of immunotherapy, including adoptive cell transfer (ACT) and immune checkpoint inhibitors (ICIs), have obtained durable clinical responses, but their efficacies vary, and only subsets of cancer patients can benefit from them. Immune infiltrates in the tumor microenvironment (TME) have ...
Spatial visualization characteristics of the tumor microenvironment In sample 1, the stromal region has two clusters, namely, cluster 0 and cluster 2. In the spatial map, cluster 0 was close to the IMPC region, and cluster 2 was farther away from the IMPC region (Fig.4A).IGKC,IGHG4, IGHG...
Integrins, which consist of two non-covalently linked α and β subunits, play a crucial role in cell–cell adhesion and cell-extracellular matrix (ECM) interactions. Among them, integrin β1 is the most common subunit and has emerged as a key mediator i
Cancer stem cells (CSCs) have the ability of self-renewal and producing heterogeneous tumor cells [6]. However, owing to their biological characteristics and the protective effect of the tumor microenvironment (TME), CSCs are less sensitive to conventional radiotherapy and chemotherapy, a phenomenon ...
(VEGF). This type of strategy, known as specific active immunotherapy, has been mostly developed in the oncological arena. VEGF is one of the most important growth factors with a relevant role on tumor angiogenesis, and it has become an attractive target for cancer immunotherapy [2]. Within ...
Esophageal squamous cell carcinoma (ESCC) is a life-threatening thoracic tumor with a poor prognosis. The role of molecular alterations and the immune microenvironment in ESCC development has not been fully elucidated. The present study aimed to elucidat