3、研究结果对于开发新的再生医学治疗方法具有重要意义,尤其是对于那些因神经-免疫相互作用失调而影响愈合的组织。 2024年3月26日,来自于澳大利亚墨尔本的莫纳什大学的Bhavana Nayer教授的研究团队在国际知名期刊《Nature》发表了题为:CGRPsensory neurons promote tissue healing via neutrophils and macrophages的研究文章。
Nature | CGRP感觉神经元通过中性粒细胞和巨噬细胞促进组织愈合 这篇论文的标题是“CGRP sensory neurons promote tissue healing via neutrophils and macrophages”,发表于《Nature》期刊。文章主要探讨了降钙素基因相关肽(CGRP)感觉神经元通过调节中性粒细胞和巨噬细胞来促进组织愈合的机制。 研究背景 免疫系统在组织愈...
进一步，研究人员利用Nav1.8cre/Rosa26tdT观察伤害感受神经元在损伤区域的分布情况，发现Nav1.8+神经元末梢长入损伤区域内的肉芽组织，说明在损伤修复过程中重新建立神经支配。2. CGRP对损伤区域免疫细胞的影响 由于Nav1.8+神经元表达CGRP、物质P、VIP和甘丙肽等分子，研究人员进一步研究CGRP是否会对损伤修复过程中的...
Nociceptive sensory neurons have a crucial role as immunoregulators and exert both protective and harmful effects depending on the context4–12. However, how neuro–immune interactions affect tissue repair and regeneration following acute injury is unclear. Here we show that ablation of the NaV1.8 ...
Chemogenetic activation of sensory neurons induced the release of calcium into the cytoplasm of cancer cells, promoting tumour growth and metastasis. Pharmacological ablation of sensory neurons or treatment with CGRP inhibitors suppressed tumour growth and extended survival. Depolarization of gastric tumour ...
CGRP sensory neurons promote tissue healing via neutrophils and macrophages Nature (2024), 10.1038/s41586-024-07237-y Google Scholar Martelletti et al., 2021 Martelletti P., Luciani M., Spuntarelli V., Bentivegna E. Deprescribing in migraine Expert Opin Drug Saf, 20 (6) (2021), pp. 62...
Oral squamous cell carcinoma (OSCC) associated pain commonly predicts adverse events among patients. This clinical feature indicates the engagement of nociceptors on sensory neurons during the development of malignancy. However, it is yet to be determine
Our study provides direct evidence that CGRPα+DRG neurons respond to agonists that evoke pain and itch and constitute a sensory circuit that is largely distinct from nonpeptidergic circuits and TRPM8+/cool temperature circuits. In future studies, it should be possible to conditionally ablate CGRP...
CGRP is produced by the sensory neurons. CGRP has multiple functions. In terms of inflammation regulation, CGRP is reported to favor inflammation and anti-inflammation. Because CGRP has a powerful function in inducing vasodilatation, and the recruitment of inflammatory cells at lesion sites, its ...
The dental pulp is a favorable model for studies of interactions between nociceptive sensory neurons and their peripheral target tissues. In the present st... Y Pan - The University of Mississippi Medical Center. 被引量: 0发表: 2003年 THE ANALYSIS OF CGRP-, SP-, NOS-IMMUNOREACTIVITY IN THE...