2024年3月26日,来自于澳大利亚墨尔本的莫纳什大学的Bhavana Nayer 教授的研究团队在国际知名期刊《Nature》发表了题为:CGRP sensory neurons promote tissue healing via neutrophils and macrophages 的研究文章。痛觉感受器神经元是一类专门的感觉神经元,它们的神经末梢分布在皮肤、肌
Nature | CGRP感觉神经元通过中性粒细胞和巨噬细胞促进组织愈合 这篇论文的标题是“CGRP sensory neurons promote tissue healing via neutrophils and macrophages”,发表于《Nature》期刊。文章主要探讨了降钙素基因相关肽(CGRP)感觉神经元通过调节中性粒细胞和巨噬细胞来促进组织愈合的机制。 研究背景 免疫系统在组织愈...
进一步，研究人员利用Nav1.8cre/Rosa26tdT观察伤害感受神经元在损伤区域的分布情况，发现Nav1.8+神经元末梢长入损伤区域内的肉芽组织，说明在损伤修复过程中重新建立神经支配。2. CGRP对损伤区域免疫细胞的影响 由于Nav1.8+神经元表达CGRP、物质P、VIP和甘丙肽等分子，研究人员进一步研究CGRP是否会对损伤修复过程中的...
CGRP sensory neurons promote tissue healing via neutrophils and macrophages Nature (2024), 10.1038/s41586-024-07237-y Google Scholar Martelletti et al., 2021 P. Martelletti, M. Luciani, V. Spuntarelli, E. Bentivegna Deprescribing in migraine Expet Opin. Drug Saf., 20 (6) (2021), pp....
During the mid-to-late repair stages, CGRP and sensory neural signaling regulated callus remodeling, mimicking the natural fracture healing process to promote osteoporotic fracture repair. This composite hydrogel was designed for the sequential release of SDF-1 and CGRP, achieving spatiotemporal ...
Therefore, a more comprehensive investigation into CGRP's roles in adipose tissue and the importance of the sensory nerve supply for WAT function and insulin sensitivity is warranted. Using intravital calcium imaging in WAT of mice, we have observed activation of tissue nerves after application of ...
PAR-2 has been expressed in two-thirds of sensory neurons, and 40% of PAR-2 expressing sensory neurons coexpress CGRP and substances-P17. Proteases such as trypsin, tryptase and cathepsin-s, activate PAR-2 and cause the release of neuropeptides from the primary spinal afferents to release ...
PAR-2 has been expressed in two-thirds of sensory neurons, and 40% of PAR-2 expressing sensory neurons coexpress CGRP and substances-P17. Proteases such as trypsin, tryptase and cathepsin-s, activate PAR-2 and cause the release of neuropeptides from the primary spinal afferents to release ...
这篇论文的标题是“CGRP sensory neurons promote tissue healing via neutrophils and macrophages”,发表于《Nature》期刊。文章主要探讨了降钙素基因相关肽(CGRP)感觉神经元通过调节中性粒细胞和巨噬细胞来促进组织愈合的机制。 研究背景 免疫系统在组织愈合中起着关键作用,调节免疫成分的再生策略已被证明是有效的。
CGRP is produced by the sensory neurons. CGRP has multiple functions. In terms of inflammation regulation, CGRP is reported to favor inflammation and anti-inflammation. Because CGRP has a powerful function in inducing vasodilatation, and the recruitment of inflammatory cells at lesion sites, its ...