2024年3月26日,来自于澳大利亚墨尔本的莫纳什大学的Bhavana Nayer 教授的研究团队在国际知名期刊《Nature》发表了题为:CGRP sensory neurons promote tissue healing via neutrophils and macrophages 的研究文章。痛觉感受器神经元是一类专门的感觉神经元,它们的神经末梢分布在皮肤、肌
这篇论文的标题是“CGRP sensory neurons promote tissue healing via neutrophils and macrophages”,发表于《Nature》期刊。文章主要探讨了降钙素基因相关肽(CGRP)感觉神经元通过调节中性粒细胞和巨噬细胞来促进组织愈合的机制。 研究背景 免疫系统在组织愈合中起着关键作用,调节免疫成分的再生策略已被证明是有效的。 ...
进一步，研究人员利用Nav1.8cre/Rosa26tdT观察伤害感受神经元在损伤区域的分布情况，发现Nav1.8+神经元末梢长入损伤区域内的肉芽组织，说明在损伤修复过程中重新建立神经支配。2. CGRP对损伤区域免疫细胞的影响 由于Nav1.8+神经元表达CGRP、物质P、VIP和甘丙肽等分子，研究人员进一步研究CGRP是否会对损伤修复过程中的...
Chemogenetic activation of sensory neurons induced the release of calcium into the cytoplasm of cancer cells, promoting tumour growth and metastasis. Pharmacological ablation of sensory neurons or treatment with CGRP inhibitors suppressed tumour growth and extended survival. Depolarization of gastric tumour ...
CGRP sensory neurons promote tissue healing via neutrophils and macrophages Nature (2024), 10.1038/s41586-024-07237-y Google Scholar Martelletti et al., 2021 P. Martelletti, M. Luciani, V. Spuntarelli, E. Bentivegna Deprescribing in migraine Expet Opin. Drug Saf., 20 (6) (2021), pp....
Using intravital calcium imaging in WAT of mice, we have observed activation of tissue nerves after application of lipids such as 13-HODE, which is an agonist of sensory nerves and leads to CGRP release. Thirty minutes after 13-HODE administration to WAT there was a significant increase in ...
CGRP is produced by the sensory neurons. CGRP has multiple functions. In terms of inflammation regulation, CGRP is reported to favor inflammation and anti-inflammation. Because CGRP has a powerful function in inducing vasodilatation, and the recruitment of inflammatory cells at lesion sites, its ...
Correspondingly, silencing of CGRPPBN neurons attenuates the expression of food neophobia and conditioned fear responses. Therefore, in addition to transducing primary sensory danger signals, CGRPPBN neurons promote affective-behavioural states that limit harm in response to potential threats. This is a ...
Calcitonin gene-related peptide (CGRP), a neuropeptide abundant in the trigeminal system and widely expressed in both the peripheral and central nervous systems, has recently emerged as a promising target for migraine management. While known as a potent arterial vasodilator, the role of CGRP in mig...
PAR-2 has been expressed in two-thirds of sensory neurons, and 40% of PAR-2 expressing sensory neurons coexpress CGRP and substances-P17. Proteases such as trypsin, tryptase and cathepsin-s, activate PAR-2 and cause the release of neuropeptides from the primary spinal afferents to release ...