However, as with inflammatory markers, expression of iNOS is increased when PROG is administered in the LPS-induced vascular inflammation model (Sunday et al., 2006). PROG treatment after ischemia results in several other effects that may contribute to neuroprotection. An increase in growth-...
Anuncibay-Soto B, Perez-Rodriguez D, Santos-Galdiano M, Font E, Regueiro-Purrinos M, Fernandez-Lopez A (2016) Post-ischemic salubrinal treatment results in a neuroprotective role in global cere- bral ischemia. J Neurochem. doi:10.1111/jnc.13651...
Thus, hyperglycemia results in decreased tissue pH in regions of focal incomplete cerebral ischemia in monkeys.doi:10.3171/jns.1986.65.5.0693Marsh, W. ... WR Marsh,RE Anderson,TM Sundt - 《Journal of Neurosurgery》 被引量: 263发表: 1986年 The glucose paradox of cerebral ischemia: evidence for...
Thrombin is upregulated after acute cerebral ischemia/reperfusion.aThe unimodal distributions of the protein intensities suggests no obvious degradation in samples.bDistribution of log2-transformed intensity of identified proteins in 6 samples. Black presents Contra, and red denotes Ipsi.cPrincipal-componen...
Reducing hyperglycemia or ROS in ischemia results in less neuronal damage. Ischemic stroke in streptozotoxin-diabetic rats resulted in larger ischemic damage and significantly higher levels of peroxynitrite. However, insulin treatment not only protected them from cerebral ischemic damage but also reduced ...
We observed a significant increase in CBF in IRL-1620-treated animals at day 7 post MCAO. It is possible that IRL-1620 could be limiting the injury due to ischemia by improving the CBF and by inhibiting the apoptotic pathway. Taken together, these results indicate that IRL-1620 improves CBF...
Vascular oxidative stress in Alzheimer disease. J Neurol Sci 2007,257 (1-2): 240-246. [11]Li J, Wang Y J, Zhang M, et al. Cerebral ischemia aggravates cognitive impairment in a rat model of Alzheimer’s disease. Life Sciences,2011,89(3-4):86-92. [12]Alex E. Roher, Zsolt ...
Here we show that tDCS treatment reduces the infarct volume after rat cerebral ischemia-reperfusion (I/R) injury and results in functional improvement of stroke animals. At the cellular and molecular level, tDCS suppresses I/R-induced upregulation of Cezanne in the ischemic neurons. Cezanne ...
and VCAM-1 mRNA and protein expression in the frontal and parietal cortex at 4, 12, 24, 48 and 72 hours following cerebral ischemia/reperfusion injury.RESULTS:Acupuncture improved neurological function and significantly decreased NF-κB, ICAM-1, and VCAM-1 mRNA and protein expression in the fron...
The RNA-Sequencing results reveal that further potential mechanisms behind the activities may be related to the anti-inflammation effects and inhibition of neuroexcitatory toxicity. Conclusion CrCi-CDs performs neuroprotective effect on cerebral ischemia and reperfusion injury, and the mechanisms may ...