Oligovascular coupling contributes to white matter vascular homeostasis. However, little is known about the effects of oligovascular interaction on oligodendrocyte precursor cell (OPC) changes in chronic cerebral ischemia. Here, using a mouse of bilatera
Transthyretin (TTR) is a protein whose function has been associated to binding and distribution of thyroid hormones in the body and brain. However, little is known regarding the downstream signaling pathways triggered by wild-type TTR in the CNS either in neuroprotection of cerebral ischemia or in...
However, it remains unclear whether honokiol or magnolol can alleviate WMI and promote remyelination after chronic cerebral ischemia. In this study, we used the bilateral carotid artery stenosis (BCAS) mouse model to induce WMI and cognitive impairment associated with chronic cerebral hypoperfusion [29...
Ischemic brain injury due to stroke and/or cardiac arrest is a major health issue in modern society requiring urgent development of new effective therapies. The aim of this study was to evaluate mitochondrial, microcirculatory, and histological changes in a swine model of global cerebral ischemia. ...
Objective This investigation was carried out with an aim of exploring neuroprotection by naringin (Nar) in rats with cerebral ischemia-reperfusion (CI/R) injury and its mechanism. Methods Rats were grouped into ischemia-reperfusion (I/R), sham operation
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Objective To dynamically observe the effects of resveratrol preconditioning on the focal cerebral ischemia.Methods Twenty SD rats were randomly divided into the resveratrol preconditioning group(n = 10)and the control group(n = 10).The rats in the preconditioning group received intraperitoneal injection...
In this review, we summarize the mechanisms of reperfusion injury and the various roles of SPMs in stroke therapy. 展开 关键词: cerebral ischemia reperfusion inflammation resolution specialized pro-resolving lipid mediators stroke DOI: 10.3389/fneur.2018.00617 年份: 2018 ...
This study investigates the protective effect of Erigeron breviscapus injection, a classic traditional Chinese medicine most typically used by Chinese minority to treat stroke, on cerebral ischemia–reperfusion injury and the related signaling pathways.
3)Hemichannels.Hemichannels, proteins involved in the formation of gap junctions, have also been proposed as non-glutamate contributors of neuronal death in ischemia22. They have been implicated in contributing to anoxic depolarization, leading to cell death in the penumbra region, as well as efflu...