Of 33 people with anticentromere antibody, 21 had CREST and two had scleroderma. Of the other 10 with a positive anticentromere antibody, three had systemic lupus erythematosus (two with digital vasculitis), three very active seronegative polyarthritis, three Raynaud's phenomenon, and one a ...
Scleroderma 20–35% Limited Scleroderma (CREST) 64–95% Diffuse Scleroderma 0–14% Sjögren's syndrome 10% Systemic lupus erythematosus 5% Non-Hodgkins lymphoma 7% 2.2.10.1 Epitopes B-cell epitopes on CENP-A are restricted to the N-terminal region [62,63]. AutoAbs to CENP-A target two ...
This assay is designed for the detection of anti-centromere IgG antibodies specifically reactive to the CENP-A and CENP-B antigens in human serum. Presence of these antibodies can aid in the diagnosis of certain connective tissue diseases such as the CREST variant of scleroderma. ...
et al. CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. Cell 70, 115–125 (1992). CAS PubMed Google Scholar Nishihashi, A. et al. CENP-I is essential for centromere function in vertebrate cells. Dev. Cell 2, 463–476 (2002). CAS PubMed...
et al. CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. Cell 70, 115–125 (1992). CAS PubMed Google Scholar Nishihashi, A. et al. CENP-I is essential for centromere function in vertebrate cells. Dev. Cell 2, 463–476 (2002). CAS PubMed...
Anti-centromere antibodies are associated with the CREST syndrome, a limited variant of the disease scleroderma. The latter is also known as systemic sclerosis. CREST comprises C for calcinosis (calcium hydroxyapatite deposition in soft tissues), R for Raynaud’s phenomenon (abnormal vascular ...
The CREST syndrome is a variant of systemic sclerosis characterized by the presence of calcinosis, Raynaud's phenomenon, esophageal motility abnormalities, sclerodactyly and telangiectasia. The serums of 27 patients with the CREST syndrome have been examined for the presence of antinuclear antibodies. ...