Scleroderma 20–35% Limited Scleroderma (CREST) 64–95% Diffuse Scleroderma 0–14% Sjögren's syndrome 10% Systemic lupus erythematosus 5% Non-Hodgkins lymphoma 7% 2.2.10.1 Epitopes B-cell epitopes on CENP-A are restricted to the N-terminal region [62,63]. AutoAbs to CENP-A target two ...
Anticentromere antibody in patients without CREST and scleroderma: association with active digital vasculitis, rheumatic and connective tissue disease. Ann Rheum Dis 1989; 48:771-5.J A Goldman. Anticentromere antibody in patients without CREST and scleroderma: association with active digital vasculitis,...
This assay is designed for the detection of anti-centromere IgG antibodies specifically reactive to the CENP-A and CENP-B antigens in human serum. Presence of these antibodies can aid in the diagnosis of certain connective tissue diseases such as the CREST variant of scleroderma. ...
Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma 91, 313–321 (1985). This paper reports the discovery of the first human centromere proteins, CENP-A, CENP-B and CENP-C, as antigens recognized by serum from patients with ...
Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma 91, 313–321 (1985). This paper reports the discovery of the first human centromere proteins, CENP-A, CENP-B and CENP-C, as antigens recognized by serum from patients with ...
Anti-centromere antibodies are associated with the CREST syndrome, a limited variant of the disease scleroderma. The latter is also known as systemic sclerosis. CREST comprises C for calcinosis (calcium hydroxyapatite deposition in soft tissues), R for Raynaud’s phenomenon (abnormal vascular ...
The antibody was not detected in the serums of patients with rheumatoid arthritis, Sjo篓rgren's sicca complex or linear scleroderma. Patients with osteoarthritis who were age- and sex-matched to the group with the CREST syndrome did not have anti-centromere antibodies. Autoantibodies found in ...