Central memory cells (TCM CD62L+ CCR7+) and their precursors, stem central memory T-cells (TSCM) possess the stem-like properties needed to reconstitute and prolong an effective immune response long-term. These
The mechanisms underlying the heightened protection mediated by central memory CD8+ T (TCM) cells remain unclear. Here we show that the transcription factor Tcf1 was required in resting TCM cells to generate secondary effector CD8+ T cells and to clear p
memory T细胞往下细分，可以分成central memory T cell和effector memory T cell，前者主要在淋巴器官里和...
having a central memory T-lymphocyte (Tcm) phenotype, said anti- third party cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, wherein said cells in suspension comprise non-hematopoietic cells or hematopoietic cells which are not stem cells. Met...
Central memory T cells (Tcm) and stem cell-like memory T cells (Tscm) are known to promote sustained proliferation and persistence after T-cell therapy, constituting essential preconditions for treatment efficacy. Therefore, we set up a protocol for anti-CD19 CAR T-cell generation aiming at ...
CD8+ T cells central memory stemness T cell factor 1 (Tcf1) (Tcf7) effector differentiation Granzyme LCMV infection vaccination Introduction Infection activates very rare antigen-specific naive CD8+ T cells (Tn), which expand and differentiate into cytotoxic effector cells (Teff) that clear pathoge...
Th2 Cells免疫记忆T淋巴细胞亚群Th1 细胞The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (TCM) and ...
In conclusion, re-directed effector- and central memory T cells specifically recognized NY-ESO-1157–165/ HLA-A*02:01-positive cells resulting in antigen-specific functionality in vitro and in vivo.This is a preview of subscription content, access via your institution ...
MATTEUCCI E;GHIMENTI M;DI B S;.Altered proportions of naive,central memory and terminally differentiated central memory subsets among CD4+and CD8+T cells expressing CD26 in patients with type 1 diabetes.J Clin Immunol.2011.977-984Matteucci E, Ghimenti M, Di Beo S, Giampietro O (2011) ...
5) memory T cell 记忆T细胞 1. Reduced frequency of CD4~+ centralmemory T cells in patients with tuberculosis 结核抗原特异性CD4~+中央型记忆T细胞的检测及分布特性研究 2. The expressions of CD62L on CD4+ and CD8+ T cells andmemory T cells were all signifcantly lower in G-BM(p values wer...