robust lipid binding facilitates drug transfer from host organelles to intracellular targets. Bedaquiline (BDQ), characterized by its lipophilicity, is an exemplary antituberculosis drug [76,77], exhibiting the capacity to
Antibody dependent cellular cytotoxicity (ADCC) is a recently described mechanism of immunologic lysis in which cellular targets sensitized by specific antibodies are efficiently and selectively lysed by Fc receptor (FcR) bearing nonspecific effectors. Immunoglobulins of various classes (IgG, IgM, IgA, Ig...
Biochemistry Determination of the Cellular Effects of Antibiofilm Therapeutics and the Characterization of Potential Cellular Targets in Bacteria NORTH CAROLINA STATE UNIVERSITY John Cavanagh StoweSean DixonThis work shows the cellular effects of 2-aminoimidazole derivatives with antibiofilm activity against the...
KasA, Pks10 and Pks11 were identified as potential targets of GSK3011724A by virtue of their reduced capturing in the presence of excess GSK3011724A. (b) Generation of IC50 values for KasA, Pks10 and Pks11. The chemoproteomic experiment was performed as in a but over a range of ...
Origins and evolution of antibiotic resistance 2010, Microbiology and Molecular Biology Reviews How antibiotics kill bacteria: From targets to networks 2010, Nature Reviews Microbiology View all citing articles on Scopus 6 These authors contributed equally to this work. ...
The development ofnew treatment options for bacterialinfectionsrequires access to new targets for antibiotics and antivirulence strategies.Chemoproteomic approaches are powerful tools for profiling and identifyingnovel druggable target candidates, but their functions often remainuncharacterized. Previously, we used...
MDR1 / P-glycoprotein extrudes a very wide array of structurally dissimilar compounds, all lipophilic and ranging in mass from approximately 300 to 2000 Da, including cytotoxic drugs that act on different intracellular targets, steroid hormones, peptide antibiotics, immunosuppressive agents, calcium ...
The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of β-lactam antibiotics in the rat small intestine. J. Pharm. Pharmacol. 49, 796–801 (1997). CAS PubMed Google Scholar Ren, Q. & Paulsen, I. T. Comparative analyses of fundamental differences in membrane...
we review the roles of multiple immunological mechanisms and therapeutic targets related to the inflammation associated with fatty liver diseases and the differences in the progression of ASH and NASH. Multiple cell types in the liver, including macrophages, neutrophils, other immune cell types and hep...
Moreover, the unique capability of GC to discern both fluorescent and label-free high-content cellular phenotypes holds potential for discovering novel targets, including gene perturbations and compounds. The fluorescence mode proves effective, particularly when the molecules or subcellular features of ...