Association of antitumor antibiotic Mithramycin with Mn2+ and the potential cellular targets of Mithramycin after association with Mn2+manganese ionoctahedral structureMithramycinmanganese superoxide dismutasechromatinMithramycin (MTR), an aureolic acid group of antit...
The molecular weight of target proteins is an important factor that affects detection efficiency. To test the lower weight limit that could be localized, we used different PBS regions with weights in the range 1.1–5.2 MD as targets (Supplementary Fig.4), and calculated the detection efficiency ...
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major types of chronic liver disease worldwide. Inflammatory processes play key roles in the pathogeneses of fatty liver diseases, and continuous inflammation promotes the progression of alcoholic steatohepatitis (A...
The mechanism of tenofovir nephrotoxicity is not clear. Tenofovir is specifically toxic to the proximal convoluted tubules and proximal tubular mitochondria are the targets of tenofovir cytotoxicity. Damaged mitochondria are major sources of reactive oxygen species and cellular damage is reported to occur ...
A study identified VEGFR-3 and Prox1 as downstream targets of the NF-κB pathway in inflammation-induced lymphangiogenesis. The induction of the NF-κB pathway by inflammatory stimuli activates Prox1, and both NF-κB and Prox1 activate the VEGFR-3 promoter, leading to increased receptor ...
95.Multifocal signal modulation therapy of cancer: ancient weapon, modern targets. 机译:癌症多灶性信号调制治疗:古代武器,现代目标。 作者:Das T;Sa G;Saha 期刊名称:《Molecular and Cellular Biochemistry: An International Journal for Chemical Biology》 | 2010年第2期 ...
cells [69]. In accordance with others [70,71], our study revealed a high prevalence of bta-miR-148a, which is found to targetDNMT1and improve the developmental capacity of porcine somatic cell nuclear transfer embryos [72]. Furthermore, studies in mice showed that miR-21 targetsPTEN[73]...
Nutrients are actively transported across cell membranes by a large class of transporter proteins called solute carriers (SLCs)9. The activity of many SLCs is influenced by the composition of the microenvironment10. Studying the function of these SLCs, and identifying potential therapeutic targets, req...
The field of cellular microbiology, rooted in the co-evolution of microbes and their hosts, studies intracellular pathogens and their manipulation of host cell machinery. In this review, we highlight emerging technologies and infection models that recent
Furthermore H-ferritin targets complex active ingredients to the cell nucleus (and therefore directly delivers DNA-binding proteins into the nucleus. Purified transferrin can be efficiently conjugated to some anticancer drugs through covalent linkers that are appropriately released inside the cells (Beyer ...