This may increase the capacity of the cell to complete DNA repair. Inhibitors of poly(ADP-ribose) polymerase or deficiencies of the substrate, NAD, lead to retardation of the DNA repair process. When DNA strand
In the last fifteen years, rapid progress has been made in delineating the cellular response to DNA damage. The DNA damage response network is composed of a large number of proteins with different functions that detect and signal the presence of DNA damage in order to coordinate DNA repair with...
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
Typically, only a subpopulation of stem cells differentiates to a given lineage with a given function. Residual stem cell subpopulations remain after the triggering stimulus for future expansion and differentiation to other lineages. So what developmental deadlines exist in the embryo, placenta, and ...
(N = 52) weeks. We likewise compared animals aged 6–26 (N = 52) vs 52–130 (N = 22) weeks, and the GSEA defined blood vessel development, basal lamina, integrin binding, cellular response to vascular endothelial growth factor stimulus, positive regulation of autophagy as ...
These reports suggest a proliferative function of p38 in contrast to the above mentioned role of p38 in stress response and cell cycle arrest. Some simple explanations for these discrepancies could be dependence on stimulus, cellular context or cell-type specificity. For example, p38 activation by ...
These functions include response to DNA damage stimulus, DNA repair, cell-cell adhesion, nucleotide excision repair, and DNA damage response and signal transduction. Using this approach (function prediction), thirty-four potential target genes of hsa-miR-590-3p were achieved. Thirty-two genes of ...
One well-documented example is the response to mating pheromone. Cells in G1 will strongly activate the MAPKs Fus3 and Kss1, unlike the S-phase cells which cannot respond to the pheromone stimulus (Oehlen and Cross, 1994; Wassmann and Ammerer, 1997). Thus, the inherent variability ...
Smale ST. Selective transcription in response to an inflammatory stimulus. Cell. 2010;140:833–44. Article CAS PubMed PubMed Central Google Scholar Belkaid Y, Segre JA. Dialogue between skin microbiota and immunity. Science. 2014;346:954–9. Article CAS PubMed Google Scholar Kim HC, Oh ...
21However, the role of NF-κB in preventing apoptosis induced by chemotherapeutic agents is controversial. We and others have established that E1A-induced cellular sensitivity to apoptosis induced by TNF-superfamily members is mediated by inhibition of stimulus-induced, NF-κB-dependent transcription.6...