Are senescence and exhaustion intertwined or unrelated processes that compromise immunity? Nat. Rev. Immunol. 11, 289–295 (2011). Article CAS PubMed Google Scholar Bursuker, I., Rhodes, J.M. & Goldman, R. Beta-galactosidase—an indicator of the maturational stage of mouse and human ...
autoregulation- (physiology) processes that maintain a generally constant physiological state in a cell or organism bacteriostasis- inhibition of the growth of bacteria bloom,blooming- the organic process of bearing flowers; "you will stop all bloom if you let the flowers go to seed" ...
An interesting feature of t(4;11)+ infant patients is the expression of MLL-AF4 in a subset of bone marrow mesenchymal stem cells (MSC) [25]. This was not observed in other types of B-ALL and seems to be unique to this group of patients. It suggests that the initial translocation o...
Despite those molecules being implied negatively in aging and numerous diseases, their key role in cellular signaling is evident. ROS control several biological processes such as inflammation, proliferation, and cell death. The redox signaling underlying these cellular events is one characteristic of the...
NAD+, the only known co-substrate for ADP-ribosylation, as well as its reduced form NADH, are essential molecules involved in regulating a plethora of cellular processes including cellular energy metabolism, gene expression, inflammation, aging, carcinogenesis, and cell death, thus linking ADP-ribosy...
(ATP)-binding cassette subfamily G member 1 and ATP-binding cassette subfamily A member 1, which are responsible for mediating the efflux of sterols or phospholipids to lipoproteins. Conversely, the expression of genes involved in sterol synthesis, such as 3-hydroxy-3-methylglutaryl-coenzyme A ...
Cellular quiescence– reversible exit from the cell cycle – is an important feature of many cell types important for organismal health. Aging and cellular dysfunction compromise the survival and reactivation of quiescent cells over time. Studies suggest that autophagic processes and lysosomal function ar...
Although effector activity and memory formation in CD8 + T cells are known to depend on mTORC1-mediated metabolic regulation, the molecular mechanisms involved are lesser known. Here authors show that NKG7, a lysosomal protein specifically expressed in CD8 + T cells, inhibits mTORC1 func...
variation of human rDNA units is likely to be highly significant, both because NORs are the locus of ribosome biogenesis and because they have also been implicated in processes as varied as cellular stress response, mitosis and cell proliferation, and specific age-related pathology (summarized in ...
Cellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors. To address this challenge, we took advantage of the controlled human ...