We conclude that upon rapid TRAIP degradation, specifically in S-phase, cells cease to proliferate, arrest in G2 stage of the cell cycle and undergo senescence. Our findings reveal that TRAIP works in S-phase to prevent DNA damage at transcription start sites, caused by replication-transcription...
Remarkably, EdU assays, DNA staining and hydroxyurea treatment showed that these terminally differentiated skin cells continue splitting despite an absence of DNA replication, causing up to 50% of SECs to exhibit reduced genome size. On the basis of a simple mathematical model and quantitative ...
a背单词是一件很痛苦的事,尤其要牢牢地记住 The back word is a very painful matter, must remember firmly especially[translate] athe virus can undergo another replication cycle in neighbouring cancer cells. 病毒在邻居癌细胞能接受另一个复制周期。[translate]...
The life of the zygote begins with the maternal DNA completing meiosis and the paternal DNA being decondensed. Each genome is then housed within separate pronuclei and undergo DNA replication before eventually existing in the same nucleus in the two-cell stage. The initial differences in chromatin...
Thus, upon PGCLC induction, female cells undergo DNA methylation reprogramming under the principle similar to that of male cells, with more acute global changes and distinct impacts on specific elements. We identified hypomethylated domains in female ESCs and demethylation-sensitive/-resistant domains ...
tumor cells undergo genome reprogramming and dedifferentiate to a progenitor/stem cell state and create a new pool of CSCs. Eventually, these therapy-resistant CSCs expand and repopulate the tumor and generate additional therapy-resistant CSC progeny. This tumor plasticity leads to tumor relapse and ...
Instead, they undergo apoptosis. Importantly, TIPIN is also required for TNBC cell tumorigenicity and its depletion slows tumor growth. In line with the renewal of interest in the targeting of DNA replication as a strategy for anti-tumor therapy, our findings suggest that TIPIN is a potentially...
RG cells serve as neural progenitors, providing structural support and guiding neuronal migration, while IPCs, derived from RGs, undergo further differentiation to generate a diverse population of neurons, contributing to the formation of the developing nervous system. Here, we asked to which extent ...
Stretched skin cells divide without DNA replicationAnalysis of zebrafish larvae reveals that epithelial cells in their skin undergo tension-driven division without DNA replication. This allows rapid expansion, enabling the cells to cover the fast-growing organism. By Aki Stubb & Sara A. Wickström ...
RTECs are particularly susceptible to cellular senescence when exposed to nephrotoxic drugs, ischemia-reperfusion injury, and other stressors associated with AKI. In addition to RTECs, podocytes, endothelial cells, immune cells, and interstitial cells also undergo stress-induced senescence [61]. Cellular...