A critical regulator of NK cell reactivity is the major histocompatibility complex (MHC I). NK and T-cells interact and interrogate MHC I complexes from different angles with different outcomes. In several examples, the outcome of these interactions is that target cells that are sensitive to killi...
Osteoimmunology investigates interactions between cells that make up the skeletal stem cell niche and immune system. Much work has investigated the complexity of the bone marrow microenvironment with respect to the skeletal and hematopoietic stem cells that regulate skeletal formation and immune health resp...
Thus, the AMPK is dispensable for the suppression of the mTORC1 pathway seen in LT-CML stem cells experiencing inhibition of Slc15A2-mediated dipeptide uptake. Smad3–Ser208 phosphorylation supports LT-CML stem cells. Although we found that dipeptides were able to influence nutrient signalling via...
we show that non-regenerative, ischemic-injured limbs are enriched with macrophages exhibiting a persistent pro-inflammatory signature. Significantly, these pro-inflammatory macrophages do not express the pro-regenerative cytokines that normally promote the proper...
49.Human Bone Marrow Mesenchymal Stem Cells Rescue Endothelial Cells Experiencing Chemotherapy Stress by Mitochondrial Transfer Via Tunneling Nanotubes 机译:人骨髓间充质干细胞通过隧道纳米管通过线粒体转移来拯救经历化疗胁迫的内皮细胞 作者:Feng Yonghuai;Zhu Rongjia;Shen Jing;Wu JiMin;Lu Wenyi;Zhang JiaMi...
quiescencesilica gelAround 20% of ovarian cancer patients exhibit chemoresistance, but there are currently no methods to predict whether a patient will respond to chemotherapy. Here, we discovered that chemoresistant ovarian cancer cells exhibit enhanced survival in a quiescent state upon experiencing ...
Poly(A)-binding protein (PABP) RNA-binding protein that binds to the poly(A) tail of eukaryotic mRNA eIF4 binding protein (4E-BP) binds and sequesters the cap-binding translation initiation factor eIF4E to suppress protein synthesis Ribosomopathies diseases that are associated with mutations in...
The number of events of micro-objects remaining in equilibrium is rare; however, HeLa cells are sometimes seen to be at equilibrium, which may be attributed to its size variation. We note that the rotation of the particles is not sensitive to whether particles are trapped at the microbubble ...
Around 20-30% of ovarian cancer patients exhibit chemoresistance, but there are currently no methods to predict whether a patient will respond to chemotherapy. Here, we discovered that chemoresistant ovarian cancer cells exhibit enhanced survival in a quiescent state upon experiencing the stress of ...
Such stem cells are said to be “totipotent.” Stem cells that are less general but that can still differentiate into several lines are called “pluripotent.” Further differentiation then occurs among the precursor cells to produce the monocyte, eosinophil, neutrophil, basophil, megakaryocytes, and...