1. T细胞CD4+记忆细胞是什么? T细胞CD4+记忆细胞是一类具有记忆功能的T细胞。当身体面对具有威胁性的抗原时,这些细胞会感应、分化并进一步成为不同类型的细胞来应对威胁。然而,在此过程中,一些细胞会留下并转变为记忆细胞,以备将来再次感应到相同抗原时能够更快地做出反应。 2. T细胞CD4+记忆细胞的功能 T细胞CD4+记...
Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function. Arthritis Res. Ther. 2008;10(2):R36. [PubMed]Brennan, F. M., Smith, N. M., Owen, S., Li, C., Amjadi, P., Green, P., Ander-...
Long-lasting memory- resting and memory-effector CD4+ T cells in human X-linked agammaglobulinemia. Blood 2002; 99:2131-7.Paroli M, Accapezzato D, Francavilla V, Insalaco A, Plebani A, Balsano F, et al. Long-lasting memory-resting and memory-effector CD4+ T cells in human X-linked...
In addition to improvements in infection, we observed that resting primary CD4 cells exposed to CD44 MicroBead treated virus tended to form microscopically visible clusters that remained up to a week in culture. Infected cells that were stimulated with αCD3 and αCD28, however, formed blasts and...
Heterogeneity of the memory CD4 T cell response: persisting effectors and resting memory T cells. J Immunol 2001; 166: 926–935. Article CAS PubMed Google Scholar Adachi M, Watanabe-Fukunaga R, Nagata S . Aberrant transcription caused by the insertion of an early transposable element in an ...
Naïve CD4+ T cells coordinate the immune response by acquiring an effector phenotype in response to cytokines. However, the cytokine responses in memory T cells remain largely understudied. Here we use quantitative proteomics, bulk RNA-seq, and single
In the absence of antiretroviral treatment, HIV-1 establishes a chronic infection that is marked by the progressive depletion of CD4+ T-cells. Of all the v... DC Douek - 《Aids Reviews》 被引量: 209发表: 2003年 What is the role of regulatory T cells in the success of implantation and...
First, many individuals present memory Ni-specific CD4+ T cell responses without having developed clinical manifestations of allergy (Cavani et al. 1998;Lisby et al. 1999). Similarly, it has been shown that the frequency of peripheral blood atopen-specific T cells is comparable in atopic and ...
Lymphocyte trafficking: CD4 T cells with a `memory' phenotype (CD45RC2) freely cross lymph node high endothelial venules in vivo. Immunology 1998;93:447±54.Sparshott SM, Bell EB. Lymphocyte trafficking: CD4 T cells with a "memory" phenotype (CD45RC- ) freely cross lymph node high ...
actual secretion by memory T cells. Differences in GrzB protein storage and secretion were observed between resting and activated memory CD4 and memory CD8 T cells. Activated memory CD4 T cells usually secreted similar amounts of GrzB compared to memory CD8 T cells (ELISpot and ELISA), despite...