Fig. 6.3. Atoh1 directs secretory cell differentiation. The basic helix-loop-helix transcription factor Atoh1 (atonal homolog 1) is regulated by Notch signaling to affect epithelial cell fate. In Notch signaling cells, NICD activates expression of transcriptional repressor(s) in the Hes family (...
ScienceDirect - Experimental Cell Research : Mesenchymal stem cells: Paracrine signaling and differentiation during cutaneous wound repair Summary We report the unexpected finding that loss of Hh signaling through conditional deletion of Smoothened (Smo) in the adult hematopoietic compartment ... AM Hockin...
而具有正常功能的人多能干细胞来源的房室结细胞的体外分化策略尚无报导。 2024年2月15日,厦门大学附属心血管病医院任洁研究员团队在Cell Stem Cell期刊发表了题为:Canonical Wnt signaling directs the generation of functional human PSC-derived atrioventricular canal cardiomyocytes in bioprinted cardiac tissues 的研...
#7074, dilution: 1:15,000). To analyse the total Smad2/3, the membrane was stripped and then incubated with Smad2/3 antibodies (Cell Signaling # 8685, clone D7G7, dilution 1:1000).
Here, we describe how cells can navigate long-range diffusion-controlled signaling via association/dissociation of spatially proximal entities. Dynamic clusters can span the cell, engaging in most signaling steps. Effective local concentration, allostery, scaffolding, affinities, and the chemical and ...
Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine signals coordinately dictate specific signaling networks that trigger the acti
Signaling pathways allow cells to detect and respond to a wide variety of chemical (e.g. Ca2+ or chemokine proteins) and physical stimuli (e.g., sheer stress, light). Together, these pathways form an extensive communication network that regulates basic c
Contact-dependent cell communication has the potential to generate elaborate cell patterns, and this occurs in vivo. We used the Delta-Notch signaling system, consisting of the ligand Delta and the receptor Notch, to construct a positive feedback loop between adjacent cells to generate a propagating...
Exosomes: Exosomes, also known as extracellular vesicles (EVs), which are produced by big multivesicular bodies (MVBs), facilitate cell-to-cell interaction by transporting bioactive cargos, across cells and efflux of undesirable molecules in healthy cells [259]. They are important signaling intercessor...
This study therefore provides further evidence for the role of estrogen signaling in breast cancer. Keywords: cell mechanics; breast cancer; estrogen; AFM; viscoelasticity; E-cadherin; confocal microscopy Graphical Abstract1. Introduction Breast cancer is a major cause of cancer-related death for ...