Physically blocking cell-cell contact or inhibiting PI3K signaling abrogated cell-cell induced proliferation, but inhibiting diffusible paracrine signaling did not. Thus, direct cell-cell contact induces proliferation in these cells. 展开 关键词: Cell shape Microcontact printing Intercellular adhesion ...
Science Cell biology What is signaling by direct contact?Question:What is signaling by direct contact?Applications of Direct Signaling:Direct signaling can be used in various contexts, such as: To communicate one's sexual orientation. To signal one's interest in an object or person. To sign...
Only marriages reversed the recent trend with a slight increase in 1994. An estimated 3,979,000 infants were born during 1994, a decline of < 1% from 1993. The birth rate was 15.3 live births per 1000 population, a 1% decline. These decreasing rates reflect a decline in the fertility ...
Cell–cell interactions may be mediated bysoluble factorsthat diffuse from one cell to the other, or mediated by physical contact/adhesions between cells (Figure I). The first category can be further classified intoautocrine signaling, where the cell produces the soluble factor that signals to itse...
Cellular signaling encompasses the ability of cells to receive, integrate, and react to signals in their surroundings. The field of signal transduction research is vast and complex. This chapter provides a modest introduction using examples of two signaling pathways. The case study, "How Cells Know...
2a for examples of the line profiling of CYK-4::GFP intensity). Within the next 30–60 s, the central spindle was established, with CYK-4 enriching rapidly in the central overlap zone and remaining there for ∼300 s until the cleavage furrow fully ingressed and the central spindle ...
DCL cells pseudocoloured in red and green are representative examples obtained from the analysis of n>3 embryos of cells located at and away from the EVL cell border, respectively. 3D volumetric projections of the DCL-EVL contact surface corresponding to the coloured DCL cells are shown on the...
(Fig.1) was rarely observed in this study. Interestingly, in the examples shown, labeled synapses are all contained in the head of spines, particularly identifiable in the sagittal section of a spine depicted in Fig.1d. Cortical glutamatergic terminals form asymmetric synapse at the head of ...
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Cell-to-cell communication between cancer cells and cells in the bone/BM niche is essential for the survival and growth of tumor cells in bone. The Notch signaling pathway is activated by cell-to-cell contact between adjacent cells and regulates proliferation, apoptosis, and differentiation in mul...