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5. Michalski, S., et al., Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature, 2020. 587(7835): p. 678-682. 6. Zhong, L., et al., Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis. Cell Discov, 2020. 6: p. 26. 7. Zhao, Y....
their activity is inhibited by Clb2/CDK-dependent cytoplasmic sequestration [64,65]. Mitosis triggers the destruction of Clb2, and thus, Swi5 and Ace2 can return to the nucleus and bind to the promoters of their target genes. Swi5 and Ace2 bind to the promoter ofCLN3to activateCLN3expr...
(which are known substrates for lipid peroxidation7,15), we hypothesized that cell cycle inhibition promotes ferroptosis resistance by enhancing DGAT-mediated TAG synthesis and lipid droplet formation; this process appears to entail the sequestration of PUFAs, preventing their incorporation into PLs and...
activity is regulated by various mechanisms, including the sequestration of cullins by CAND1, the conjugation of the ubiquitin-like protein NEDD8 at lysine residues located in the C-termini of cullins, and the degradation of CRL components....
5. Michalski, S., de Oliveira Mann, C.C., Stafford, C.A., Witte, G., Bartho, J., Lammens, K., Hornung, V., and Hopfner, K.P. (2020). Structural basis for sequestration and autoinhibition of cGAS by ch...
(ST3GAL1) as a negative regulator of the cancer-specific migration of CAR T cells. Analysis of glycosylated proteins revealed that CD18 is a major effector of ST3GAL1 in activated CD8+T cells. ST3GAL1-mediated glycosylation induces the spontaneous nonspecific tissue sequestration of T cells by...
Chronic stress responses can be as damaging as the hazards they counteract. Here the authors show how a blindness-induced brain-wide stress response is dampened by sequestration of transcription factors in cytosolic granules. Shashank Shekhar