Dalko E, D Genete, F Auger, C Dovergne, C Lambert, F Herbert, PA Cazenave, J Roland, and S Pied. Heme dampens T-cell sequestration by modulating glial cell responses during rodent cerebral malaria. Brain Behav Immun 2016.58:280-290....
sequestration of T cells by altering lymphocyte function-associated antigen-1 (LFA-1) endocytic recycling. Engineered CAR T cells with enhanced expression of βII-spectrin, a central LFA-1-associated cytoskeleton molecule, reversed ST3GAL1-mediated nonspecific T cell migration and reduced tumor growth...
CXCL12-CXCR4 轴在从肿瘤区域隔离【sequestration[ˌsiːkwəˈstreɪʃn]封存;扣押;隔离;没收;螯合作用】 CTL 以减少 CTL 浸润和介导免疫抑制细胞浸润到肿瘤中起间接作用。在 PDAC 模型中,用 CXCR4 抑制剂 AMD3100 抑制 CAF 介导的 CXCL12/CXCR...
Brain tumors such as glioblastomas are resistant to immune checkpoint blockade therapy, largely due to limited T cell infiltration in the tumors. Here, we show that mice bearing intracranial tumors exhibit systemic immunosuppression and T cell sequestration in bone marrow, leading to reduced T cell ...
et al. Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion. Nature Med. 19, 465–472 (2013). PubMed CAS Google Scholar Kenter, G. G. et al. Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N. Engl. ...
A consistent hallmark of severe COVID-19 is T cell lymphopenia (Chen et al., 2020a; Zhao et al., 2020a), which is unlikely to simply reflect T cell sequestration in infected lungs (Liao et al., 2020). Importantly, although overall T cell lymphopenia is observed, the frequencies of ...
and sequestration of iRBC into the gut [123,143] possibly resulting into gut tissue damage and microbial translocation, thus activating gut- and liver-homing MAIT cells. Hence, MAIT cells are emerging as an unconventional T cell population involved and possibly contributing to anti-P. falciparumT...
These results demonstrate that besides facilitating cell adhesion, LFA-1 serves as a potent co-stimulatory molecule by inducing different cytokine patterns depending on the ligand bound. 展开 关键词: LFA-1 Co-stimulatory molecule Cytokine Cellular proliferation T lymphocytes ...
The application of chimeric antigen receptor (CAR) T cells in the management of hematological malignancies has emerged as a noteworthy therapeutic breakthrough. Nevertheless, the utilization and effectiveness of CAR-T cell therapy in solid tumors are sti
The contribution of epitope spreading to chronic CNS demyelination could be considered to be a special case since tolerance to myelin epitopes would be expected to be inefficient due to their sequestration behind the blood-brain-barrier. However, the recent description of epitope spreading in response...