Pancreatic β-cells are responsible for production and secretion of insulin in response to increasing blood glucose levels. Defects in β-cell function lead to hyperglycemia and diabetes mellitus. Here, we show that CNOT3, a CCR4–NOT deadenylase complex subunit, is dysregulated in islets in diab...
Effects of metformin on cancer in type 2 diabetics could be secondary to reduction in insulin levels, and although there is evidence for direct effects of AMPK activation on the development of tumors in mice, there is also recent evidence that tumors that become established without down-regulating...
Sec and Tat are the two distinct, key pathways in bacteria responsible for translocating secretory proteins across the cytoplasmic membrane (Figure 2). The industrial standard is Sec, which transports proteins in an unfolded state, often followed by periplasmic oxidative folding. By contrast, the Tat...
Schwann cells, responsible for the normal maintenance and regeneration of peripheral nerves, were formed into spheroids after phenotype induction from ASCs. Following implantation into a rat spinal cord injury model, local increases in myelin and neurotrophic factors promoted neuronal repair88. Following ...
Gibco sera for bioprocessing can support your cell culture needs as you scale up production. As one of the largest serum suppliers from BSE-negligible risk regions, Gibco serum can help meet biopharmaceutical manufacturing requirements. Learn more about sera for bioprocessing ...
Fetal bovine serum (FBS), also known as fetal calf serum, offers essential nutrients and growth factors for the maintenance and growth of cultured cells. Cell-based applications are an integral part of basic research, biochemical studies, vaccine development, and drug discovery to name a few....
The cause of macular holes is still unknown; however, one study has stated that tangential vitreous traction may be responsible for macular holes [84]. Preclinical studies have demonstrated that systematic inoculation of MSC-Exos alleviates inflammation and damage in macular degeneration [85]. An ...
A potential therapeutic strategy for diabetes is the transplantation of induced-insulin secreting cells. Based on the common embryonic origin of liver and
Further studies using Sting1 mutant mice suggest that STING1-mediated autophagy (but not STING1-dependent IFN production) is responsible for anti–HSV-1 responses52, although HSV may also counter this STING1-mediated autophagy induction in vivo53. This autophagy-dependent antiviral function is also...
Little is known about GEC and potential inflammation in AS. The pathway enrichment analysis suggested that immune system mechanisms are regulated in GEC (Fig.5F, G). The AS-dimtdTGEC overexpressed gene sets responsible for chemokine production and secretion (Fig.6A). In contrast, expression of ...