For a given box plot, any cell type signature score is the sum of log-transformed CPM-TMM normalized counts. The horizontal line denotes the median; the lower hinge indicates the 25th percentile; the upper hinge indicates the 75th percentile; whiskers indicate the 1.5 interquartile range; and ...
Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in radiosensitivity of esophageal squamous cell carcinoma (ESCC). However, the underlying mechanism is not completely understood. Here, we observed that IGFBP-3 had favorable impact on the tumorigenicity of ESCC cells in...
These results suggest that the EC2 likely has functions similar to SC2 to provide the inflammatory niche required for vascular network development. The EC3 highly expressed Fibronectin 1 (FN1) and its binding protein, insulin-like growth factor binding protein 3 (IGFBP3) (Beattie et al. 2009)...
(TGF-β),insulin growth factors1 and 2 (IGF-1 and IGF-2), and seminiferous growth factor (SGF) orstem cell factor(SCF). Some of these growth factors, such as TGF-α, TGF-β, and IGF-1, are involved in the regulation ofLeydig cellfunction. Other secreted substances includeclusterin, ...
theTHY1+cells. These results suggest that the EC2 likely has functions similar to SC2 to provide the inflammatory niche required for vascular network development. The EC3 highly expressed Fibronectin 1 (FN1) and its binding protein, insulin-like growth factor binding protein 3 (IGFBP3) (Beattie...
Blood sugar, diabetes:: high glucose levels, big fluctuations in glucose levels, diabetes mellitus, and more. Histamineaffects insulin production, but the range of instability in patients using continuous blood glucose monitors is significant, so I hope we get more data as to why this happens, ...
These cells have been proposed to support the hematopoiesis procedure by expression of surface markers including E-Selectin and up-regulation of ‘angiocrine’ factors such as fibroblast growth factor 2 (FGF2), delta-like 1 (DLL1), insulin-like growth factor-binding protein 2 (IGFBP2), ...
Despite the growing health and economic burden, there are no approved therapeutic options for NASH4. Therapeutic strategies currently being pursued reflect the heterogeneous pathogenesis of NASH and focus on specific biochemical pathways and nodes, including those associated with insulin resistance, lipo...
First, we assessed changes in cell type abundances, which revealed an enrichment in T- and NK cells, and a depletion of B- and myeloid cells in NB metastases compared to controls. Other cell types displayed marginal differences between NB patients and controls (Fig. 4a, Supplementary Fig. 4a...
MSC-Exos for Type 1 diabetes mellitus (T1DM) T1DM is an autoimmune disease that is caused by the destruction of insulin-secreting pancreatic β-cells that leads to the elevation in glucose levels in the blood (hyperglycemia) [77]. Currently, there is no cure for T1DM, and treatment with in...