Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs Immunity, Volume 52, Issue 4, 14 April 2020, Pages 716-718 Katherine Oherle, Elizabeth Acker, Madeline Bonfield, Timothy Wang, Jerilyn Gray, Ian Lang, James Bridges,...
Type I diabetes, or insulin-dependent diabetes, results from the cellular-mediated autoimmune de-struction of pancreatic islet cells that are known to produce insulin. Type I diabetic patients experience high blood glucose levels as a result of insulin deficiency. There is no cure for this form ...
Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in radiosensitivity of esophageal squamous cell carcinoma (ESCC). However, the underlying mechanism is not completely understood. Here, we observed that IGFBP-3 had favorable impact on the tumorigenicity of ESCC cells in...
Obesity is a worldwide epidemic, with the number of overweight and obese individuals climbing from just over 500 million in 2008 to 1.9 billion in 2014. Type 2 diabetes (T2D), cardiovascular disease and non-alcoholic fatty liver disease have long been as
In the group of hormones the most common are hydrocortisol and insulin [52, 73, 79] Physico‐chemical properties of cultures in vitro Potential hydrogen (pH) For animal and human cells a pH was determined in the range of 7.0 -7.4. Some differences can be noticed for transformed cells (...
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes have been debated extensively. The con
if both cell populations grown in co-culture were able to establish direct cell–cell contacts [151]. In addition, AE2-cell-derived factors may affect extracellular matrix formation by fibroblasts, such as stimulation of collagen type I secretion by AE2-cell-derived insulin-like growth factor (...
β-Cell loss in Type 2 diabetes is slower than in Type 1 diabetes, typically with a long phase of β-cell dysfunction, characterized by defective insulin secretion in response to glucose. In Type 2 diabetes, glucolipotoxicity, rather than proinflammatory cytokines, is considered to be an import...
cells. Rare bronchioalveolar stem cells (BASCs), co-expressingScgb1a1andSftpc, can be found in the bronchioalveolar duct junction. The alveoli are lined by cuboid alveolar type 2 cells (AT2) specialized in surfactant secretion, and flat alveolar type 1 cells (AT1) responsible for gas ...
Insulin: 3 DSBs Bacillus spp. Batch bioreactor Culture medium 1000 mg/l [113] E. coli Fed-batch bioreactor Cytoplasm 4340 mg/l* [114] S. cerevisiae Shake flask Culture medium 79 mg/l [115] P. pastoris Fed-batch bioreactor Culture medium 3075 mg/l [116] CHO T-75 flasks Culture medium...