Embryonic stem (ES) cells offer great potential for cell replacement and tissue engineering therapies because of their almost unlimited proliferation capacity and the potential to differentiate into cellular derivatives of all three primary germ layers. This chapter describes a strategy for the in vitro...
insulin-producing cells by introduction of the pancreatic duodenal homeobox-1 (PDX-1). Recombinant adenoviral vector was used to deliver PDX-1 gene into hMSCs. After being infected with Ad-PDX-1, hMSCs were successfully induced to differentiate into insulin-secreting cells. The differentiated PDX-...
Mesenchymal stromal cells (MSCs) are an attractive option for cell therapy for type 1 diabetes mellitus (DM). These cells can be obtained from many sources, but bone marrow and adipose tissue are the most studied. MSCs have distinct advantages since they are nonteratogenic, nonimmunogenic and ...
This study investigated the anti-photoaging effects of SPE on UV-induced damage in human keratinocyte HaCaT cells and SKH-1 hairless mice. Methods: SPE was evaluated for its ability to mitigate UV-induced damage in HaCaT cells by assessing MMP-1 protein and mRNA expression levels, as ...
The purpose of the present invention is to provide a novel method for making it possible to efficiently induce/produce endocrine cells from pluripotent stem cells. Insulin-producing cells including cells that are insulin-positive and NKX6.1-positive in a ratio of at least 30%, and cells that ar...
Insulin-producing cells (IPCs), functionally analogous to mammalian pancreatic islet β cells, are medially located in the central brain. IPCs play a key role in regulating Drosophila growth and metabolism. Blocking or ablation of IPCs results in severely reduced body size and delayed development7,...
Efficient differentiation of insulin-producing cells from skin-derived stem cells W. Guo*, C. Miao*, S. Liu*, Z. Qiu*, J. Li* and E. Duan* *State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing, China , and ?Graduate...
Mesenchymal stromal cells (MSCs) can be obtained from various tissues for differentiation into insulin-producing cells (IPCs) [34,61,69,72,77]. The adipose tissue offers distinct advantages due to its availability and significant therapeutic potential, characterized by its intrinsic regenerative ...
andthatsuchcellscanbeseparatedbyFACS. Ó2006ElsevierInc.Allrightsreserved. Keywords:Angiogenesis;b-Cell;Development;Diabetes;EScells;FACS;GFP;Insulin;Pancreas;PDX-1 Transplantationofpancreaticisletshasemergedasa possibletreatmenttoalleviateinsulindeficiencyindiabetic ...
Keywords: Extracellular Matrix; Proliferation; Differentiation; ARIP Cells; Incretin GLP-1doi:10.4236/jbise.2009.24035Gary G. AdamsYu-Xin CuiScientific ResearchJournal of Biomedical Science & Engineering