1 and 2). The single-cell data also allows for examining how the overall tissue architecture and cellular composition change between a normal and disease state. Critically, in line with known disease pathology1,38, we noted a drastic increase in the percentage of SMC cells in UF tumors (...
The average expression of each gene in all the cells was calculated with the rowMeans command. For the bulk data, expression matrices were downloaded from the GEO database. The expression data were merged for both the single-cell data and bulk data for the overlapping genes. The expression ...
270,271 In vitro and in vivo studies have demonstrated that the IDH1 mutation reduces the aggressiveness of an established glioma cell line.272 The discovery of the role of IDH1/IDH2 in gliomas has important implications. First, this enzyme previously had no known role in tumor formation, and...
GDSC gene-level mutation and methylation data (numbers in red) were prepared from raw data as part of the development of CellMinerCDB. Asterisks indicate molecular data under development, but not publicly available. Protein expression was determined by reverse-phase protein array. (C) Cell line ...
Functionally, USP22 depletion suppressed tumorigenesis in B16-F10 cell line. Furthermore, USP22 depletion down-regulated PD-L1 protein level while promoted T cell-mediated cell killing. The positive correlation of USP22 and PD-L1 expression in human tumor samples implied the possibility that USP22...
While transfer of 3 × 106 cells expressing TCR 1 was no longer sufficient for complete tumor rejection against the less-immunogenic parental cell line, tumor growth was still significantly delayed compared to untreated mice or mice receiving 3 × 106 polyclonal activated CD4+ T cells (...
Tighe, L., Forster, A., Clark, D. M., Boylston, A. W., Lavenir, I., and Rabbitts, T. H. Unusual forms of T cell γ mRNA in a human T cell leukemia cell line: implications for γ gene expression.Eur J Immunol 17:1729–1736, 1987 ...
In line with somatic mutation frequency, correlation analysis further exhibited that TRLS was positively correlated with mRNA-si and TMB (Fig. 6C, D). The number of neoantigens was profoundly increased in the high TRLS group (Fig. 6E). Compared to patients with low TRLS, patients with ...
AHR and ALDH1A3 expression in human cancer cell lines From Cancer Cell Line Encyclopedia (CCLE) AHR ChIP-seq data Available from the database (CHIP-ATLAS) RNA-seq data Provided as Supplementary tables Source data for AHR gene expression Included with the paper 代码表格 数据资源获取方式 Packages...
denotezijthe observed value of geneion cell linej, andxijits discrete hidden state.zijwas first rank-transformed into the cumulative distribution function (CDF) valueyij. Families of polynomial quantization functionsfγ(yij)≡yijγandf¯γ(yij)≡(1-yij)γthen convertedyijinto the probabilities ...