Cell death is essential for maintaining homeostasis during development by eliminating senescent, damaged infected and aberrant cells [1,2]. The process can be non-immunogenic (apoptosis) and immunogenic and pro-inflammatory (necrosis) [3]. The regulated necrosis is modulated by the genetically program...
In the early to mid-19th century, cellular death, also known as necrosis, was reported by Carl Vogt and Rudolf Virchow, among others4,5. In 1972, a new type of cell death distinct from necrosis, called apoptosis, was reported by John Kerr6. Since then, many other types of cell death ...
Classically, cell death is categorized primarily into four different types: apoptosis, autophagy, necrosis, and entosis; depending on cellular and molecular signatures governing the pathway involved. The purpose of this review is to compare and contrast the recent literature on cell death and to ...
ultimately leading to cell death [71]. In addition to common membrane repair mechanisms, such as the endosomal sorting complex needed for transport-III [72,73], various antioxidant enzymes or proteins play a context-dependent role in selectively inhibiting oxidative cell death in cancer cells. ROS...
Cell death, serving as a crucial regulatory mechanism, significantly contributes to the maintenance of the body’s internal homeostasis and the equilibrium of cell populations [7]. In recent years, there has been significant progress in the development of pharmaceutical agents that specifically target ...
Organellophagy regulates cell death Organellophagy and cell death in inflammatory diseases Conclusions and clinical perspectives Compliance with ethics requirements Declaration of competing interest Acknowledgements References VitaeShow full outline Cited by (1) Figures (6) Tables (2) Table 1 Table 2Jour...
In recent years, programmed cell death (PCD) is considered to be a critical process after SCI, and various forms of PCD were discovered in recent years, including apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis and paraptosis. Unlike necrosis, PCD is known as an active cell death ...
protein activation cascades and modulation of gene expression. Although programmed cell death has been usually identified as a synonymous of apoptosis, it also includes different caspase-independent death programs such as autophagy,paraptosis,necroptosisormitotic catastrophe(Broker et al., 2005; de Brui...
cell death. This form of cell death can take various forms, such as ferroptosis, apoptosis, necroptosis, pyroptosis, paraptosis, parthanatos, and oxeiptosis, each displaying distinct genetic, biochemical, and signaling characteristics. The investigation of oxidative cell death holds promise for the ...
Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an undesirable but unavoidable final outcome of nonfunctioning cells, as inflammation was inevitably trigger