Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an undesirable but unavoidable final outcome of nonfunctioning cells, as inflammation was inevitably triggered in response to damage. However, experimen...
ultimately leading to cell death [71]. In addition to common membrane repair mechanisms, such as the endosomal sorting complex needed for transport-III [72,73], various antioxidant enzymes or proteins play a context-dependent role in selectively inhibiting oxidative cell death in cancer cells. ROS...
Programmed cell death (PCD) is the universal process that maintains cellular homeostasis and regulates all living systems' development, health and disease. Out of all, apoptosis is one of the major PCDs that was found to play a crucial role in many disease conditions, inclu...
Taken together, the data indicate that hesperidin induces paraptosis like cell death in HepG2 cells with the activation of ERK1/2. Thus our finding suggests that hesperidin inducing paraptosis may offer an alternative tool in human liver carcinoma therapy. 展开 ...
Cell death, serving as a crucial regulatory mechanism, significantly contributes to the maintenance of the body’s internal homeostasis and the equilibrium of cell populations [7]. In recent years, there has been significant progress in the development of pharmaceutical agents that specifically target ...
protein activation cascades and modulation of gene expression. Although programmed cell death has been usually identified as a synonymous of apoptosis, it also includes different caspase-independent death programs such as autophagy,paraptosis,necroptosisormitotic catastrophe(Broker et al., 2005; de Bru...
reactive cell death (pyroptosis and NETosis), as well as other types, such as necroptosis. Finally, necrosis represents a form of non‑programmed cell death. 1. Introduction Cell death, survival, proliferation and differentiation represent fundamental processes of life. Cell death plays a pivotal...
ferroptosis, necroptosis, autophagic cell death, mitotic catastrophe, paraptosis, and pyroptosis, as well as its role in efferocytosis which is the process ... Ranjan,Atul,Iwakuma,... 被引量: 16发表: 2016年 程序性细胞死亡机制的研究进展 (autophagic cell death),类凋亡/副凋亡(paraptosis),细胞有...
CREB-binding protein (CBP) is an acetyltransferase known to play multiple roles in the transcriptions of genes involving oxidative metabolism, cell cycle, DNA damage checkpoints, and cell death. In this study, CBP was found to positively regulate the exp
cell death. Thus, dysfunctional cellular pathways eventually lead or contribute to various age-related diseases, such as neurodegenerative, cardiovascular and metabolic diseases. Thus, mitochondrion-associated programmed cell death-based treatments show great therapeutic potential, providing novel insights in ...